ReviewGynecologic oncology reports2021
Diffusion-weighted MRI to detect early response to chemoradiation in cervical cancer: A systematic review and meta-analysis.
Review in Gynecologic oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of qualitative Diffusion weighted imaging and apparent diffusion coefficient (DWI/ADC) on target volume delineation in cervical cancer: a feasibility study.Technical innovations & patient support in radiation oncology · 2026Article
- Multimodality and temporal analysis of cervical cancer treatment response.Quantitative imaging in medicine and surgery · 2026Article
- Locally Advanced Cervical Cancer: Multiparametric MRI in Gynecologic Oncology and Precision Medicine.Diagnostics (Basel, Switzerland) · 2025Review
- Multi-institution longitudinal apparent diffusion coefficient measurements in a diffusion weighted imaging phantom at room temperature.Physics and imaging in radiation oncology · 2025Article
- Primary staging with 2[18F]-FDG-PET/CT and -PET/MRI and radiotherapy response evaluation with MRI in uterine cervical cancer: an interim analysis of a prospective clinical trial.EJNMMI reports · 2025Article
- Baseline and early response 2-[18F]FDG-PET/MRI for prediction of radiotherapy outcome in uterine cervical squamous cell carcinoma: a prospective single-center observational cohort study.EJNMMI reports · 2024Article
- Staging of Cervical Cancer: A Practical Approach Using MRI and FDG PET.AJR. American journal of roentgenology · 2023Review
- An Update on the Role of MRI in Treatment Stratification of Patients with Cervical Cancer.Cancers · 2023Review
- A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors.Insights into imaging · 2023Article
- Diffusion-Weighted Magnetic Resonance Imaging: Clinical Potential and Applications.Journal of clinical medicine · 2022Article
- Multi-parametric PET/MRI for enhanced tumor characterization of patients with cervical cancer.European journal of hybrid imaging · 2022Article
- Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiffusion-weighted magnetic resonance imaging (DWI) has shown promise in predicting response to therapy in several malignancies. This systematic review and meta-analysis aimed to evaluate DWI in the prediction of response to treatment in patients with cervical cancer.
methodsA systematic search was conducted on PubMed, Web of Science, Cochrane and Google Scholar databases Studies that evaluated DWI and apparent diffusion coefficient (ADC) for response evaluation before, during and after treatment with a correlation to conventional response criteria were included. The primary endpoint was the mean ADC values of cervical cancer at these timepoints. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess the quality of the studies.
resultsNine studies, comprising 270 patients, were included. Pre-treatment ADC values showed no correlation with eventual response. However, in our meta-analysis, there was a significant correlation with early treatment ADC values obtained within the first 3 weeks of therapy and response, as well as a significant correlation with the percentage change in ADC (ΔADC) and response. In addition, the pooled mean ΔADC percentage was also significantly higher in responders than in non-responders (49.7% vs 19.7%, respectively, p = 0.016).
conclusionDWI shows potential as a biomarker of early treatment response in patients with cervical carcinoma. Use of the change in ADC particularly within the first 3 weeks of therapy seems to be predictive of response and may serve as a suitable marker in the determination of early response.
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