Evidence map›Paper›PMID 34926729›Full record

ArticleBone reports2021

Micropetrosis in hemodialysis patients.

Aiji Yajima, Ken Tsuchiya, David B Burr, Taro Murata, Masaki Nakamura, Masaaki Inaba, Yoshihiro Tominaga, Tatsuhiko Tanizawa, Takashi Nakayama, Akemi Ito and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Aiji YajimaDepartment of Anatomy, Cell Biology and Physiology, Indiana University, School of Medicine, Indianapolis, IN, USA.
Ken TsuchiyaDepartment of Blood Purification, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
David B BurrDepartment of Anatomy, Cell Biology and Physiology, Indiana University, School of Medicine, Indianapolis, IN, USA.
Taro MurataDepartment of Urology, Tokyo Teishin Hospital, Tokyo, Japan.
Masaki NakamuraDepartment of Nephrology and Urology, NTT East Kanto Hospital, Tokyo, Japan.
Masaaki InabaDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yoshihiro TominagaDepartment of Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan.
Tatsuhiko TanizawaDepartment of Orthopedic Surgery, Tanizawa Clinic, Niigata, Japan.
Takashi NakayamaDepartment of Orthopedic Surgery, Towa Hospital, Tokyo, Japan.
Akemi ItoIto Bone Histomorphometry Institute, Niigata, Japan.
Kosaku NittaDepartment of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Tokyo Women's Medical University · JPIndiana University – Purdue University Indianapolis · USJapanese Red Cross Nagoya Daini Hospital · JPKanto Central Hospital · JPOsaka City University · JPTokyo Teishin Hospital · JPTowa Pharmaceutical (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid, which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular system regardless of bone turnover of the patients. And microcracks are predisposed to increase in these areas, which leads to increased bone fragility. However, micropetrosis of hemodialysis (HD) patients has not been discussed at all. Micropetrosis area per bone area (Mp.Ar/B·Ar) and osteocyte number per micropetrosis area (Ot.N/Mp.Ar) were measured in nine HD patients with renal hyperparathyroidism (Group I), twelve patients with hypoparathyroidism within 1 year after the treatment of renal hyperparathyroidism (Group II) and seven patients suffering from hypoparathyroidism for over two years (Group III). And bone mineral density (BMD) and tissue mineral density (TMD) were calculated using μCT to evaluate bone mineral content of iliac bone of the patients. These parameters were compared among the three groups. Only Mp.Ar/B·Ar was statistically greater in Group II and III compared to Group I in the parameters of bone mineral content and micropetrosis. However, the other parameters were not statistically different among the three groups. In long-term HD patients, BMD and TMD may be modified by the causes of renal insufficiency and the treatment of renal bone disease. We concluded that Mp.Ar/B·Ar was greater in patients with long-term hypoparathyroidism than both those with short-term hypoparathyroidism and with renal hyperparathyroidism. Special attention should be paid to avoid long-term hypoparathyroidism of the patients from the view point of increased fracture risk caused by increased micropetrosis area.

Indexed as

Bone histomorphometryFracture riskHemodialysis patientsMicropetrosisμCT

Identifiers

PMID34926729
PMCPMC8649646
OpenAlexW3217344148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.