Evidence map›Paper›PMID 34926717›Full record

ArticleOncoscience2021

Berry anthocyanidins inhibit intestinal polyps and colon tumors by modulation of Src, EGFR and the colon inflammatory environment.

Ashley M Mudd, Tao Gu, Radha Munagala, Jeyaprakash Jeyabalan, Mostafa Fraig, Nejat K Egilmez, Ramesh C Gupta

Open access · diamondAbstract read
In one paragraph

Article in Oncoscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ashley M MuddDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Tao GuDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.
Radha MunagalaJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Jeyaprakash JeyabalanJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Mostafa FraigDepartment of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY 40202, USA.
Nejat K EgilmezDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.
Ramesh C GuptaDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
University of Louisville · USJames Graham Brown Foundation · US

Funding

UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
Integrating innate and adaptive immunity in cancer therapyR01CA100656 · NCI · UNIVERSITY OF LOUISVILLE · PI EGILMEZ, NEJAT K · 2004 to 2014
$2.9M
Oral Immune Modulatory Adjuvants for Treatment of Colorectal CarcinomaR21AI092133 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EGILMEZ, NEJAT K · 2011 to 2012
$453k
NCI NIH HHS R01 CA100656NIAID NIH HHS R21 AI092133NIEHS NIH HHS T32 ES011564
6 · The paper itself

Abstract

Colorectal cancer is the third most common form of cancer diagnosed and the third leading class for cancer-related deaths. Given the prevalence of colon cancer worldwide, further insight into developing novel and effective prevention and treatment strategies are warranted. The family of plant pigments known as the anthocyanins has been identified with a variety of health benefits including chemopreventive and therapeutic effects. A limitation to current clinical applications of anthocyanins is the high doses that are required. In order to overcome this limitation, we tested the active moiety, anthocyanidins for chemopreventive and therapeutic effects against colorectal cancer

Indexed as

anthocyanidinsbilberrycolorectal cancerfamilial adenomatous polyposisPD-L1

Identifiers

PMID34926717
PMCPMC8664094
OpenAlexW4205217137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.