ArticleFrontiers in oncology2021
Intracellular Water Lifetime as a Tumor Biomarker to Monitor Doxorubicin Treatment
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.Magma (New York, N.Y.) · 2026Article
- Clinical predictors of overall survival in pediatric patients with intramedullary spinal tumors: an analysis of the SEER database.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Understanding water properties in tumorous murine cells using field-cycling NMR relaxometry.Scientific reports · 2025Article
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- Field cycling imaging to characterise breast cancer at low and ultra-low magnetic fields below 0.2 T.Communications medicine · 2024Article
- Markers of low field NMR relaxation features of tissues.Scientific reports · 2024Article
- Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice.Communications biology · 2023Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to explore whether the water exchange rate constants in tumor cells can act as a hallmark of pathology status and a reporter of therapeutic outcomes. It has been shown, using 4T1 cell cultures and murine allografts, that an early assessment of the therapeutic effect of doxorubicin can be detected through changes in the cellular water efflux rate constant k
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.