Evidence map›Paper›PMID 34926214›Full record

ArticleInternational journal of ophthalmology2021

Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study.

Ling Ling, Wen-Feng Liu, Yu Guo, Rong-Bin Liang, Hui-Ye Shu, Li-Juan Zhang, Qiu-Yu Li, Qian-Min Ge, Yi-Cong Pan, Yi Shao

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Article in International journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ling LingAffiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Wen-Feng LiuDepartment of Hepatic Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yu GuoDepartment of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Rong-Bin LiangDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Hui-Ye ShuDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Li-Juan ZhangDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Qiu-Yu LiDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Qian-Min GeDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Yi-Cong PanDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Yi ShaoDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess changed spontaneous brain activity in hyperthyroid exophthalmos (HE) patients by the amplitude of the low-frequency fluctuation (ALFF) method, and to analyze the correlation between brain activity and ALFF values in these patients.

methodsTotally 18 HE and 18 hyperthyroid non-exophthalmos (HNE) patients were enrolled. The participants were tested by resting-state functional magnetic resonance imaging, and receiver operating characteristic (ROC) curves were generated to classify the ALFF values of the study population. Pearson's correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical manifestations.

resultsContrary to HNE patients, we observed lower ALFF values in the left calcarine fissure and surrounding cortex (LCFSC) in HE patients. In the ROC curve analysis of the LCFSC, the area under the curve reflected a high degree of accuracy. In addition, there was positive correlation between mean ALFF values of the LCFSC and the best-corrected visual acuity of the affected eyes.

conclusionThe study displays abnormal brain activity in LCFSC in patients with HE, which might suggest pathological mechanism of visual impairment of HE patients.

Indexed as

amplitude of low-frequency fluctuationfunctional magnetic resonance imaginghyperthyroid exophthalmosspontaneous brain activity

Identifiers

PMID34926214
PMCPMC8640773

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