ArticleInternational journal of ophthalmology2021
Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema.
Article in International journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy.Metabolites · 2025Review
- Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy.Frontiers in medicine · 2025Article
- Optical Coherence Tomography Angiography as a Diagnostic Tool for Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2024Review
- Quantitative Parameters Relevant for Diabetic Macular Edema Evaluation by Optical Coherence Tomography Angiography.Medicina (Kaunas, Lithuania) · 2023Review
- Epiretinal membrane related vascular changes in diabetic eyes evaluated with optical coherence tomography angiography.International journal of ophthalmology · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
aimTo quantitatively detect aqueous levels of angiopoietin-like (ANGPTL)3, ANGPTL4, and ANGPTL6 and investigate their correlation with optical coherence tomography angiography (OCTA) findings in patients with diabetic macular edema (DME).
methodsThis cross-sectional study included 23 patients (27 eyes) with type 2 diabetes and 16 control subjects (20 eyes). All patients underwent OCTA imaging and ultra-wide field fundus photography. Diabetic patients were categorized into two groups according to the presence or absence of diabetic retinopathy (DME group, 14 patients, 16 eyes); and non-diabetic retinopathy (NDR) group, 9 patients, 11 eyes, respectively. Aqueous levels of ANGPTL3, ANGPTL4, and ANGPTL6 were assessed using suspension array technology, and foveal-centered 3×3 mm
resultsAqueous ANGPTL3 levels were not significantly different among the three groups (
conclusionANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME therapy. In addition, OCTA metrics may be useful for evaluating macular ischemia in DME.
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