Evidence map›Paper›PMID 34926126›Full record

ArticleIn silico pharmacology2022

Using mathematical modeling to estimate time-independent cancer chemotherapy efficacy parameters.

Christine Pho, Madison Frieler, Giri R Akkaraju, Anton V Naumov, Hana M Dobrovolny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine PhoDepartment of Physics and Astronomy, Texas Christian University, 2800 S. University Drive, Fort Worth, 76129 TX USA.
Madison FrielerDepartment of Biology, Texas Christian University, 2800 S. University Drive, Fort Worth, 76129 TX USA.
Giri R AkkarajuDepartment of Biology, Texas Christian University, 2800 S. University Drive, Fort Worth, 76129 TX USA.
Anton V NaumovDepartment of Physics and Astronomy, Texas Christian University, 2800 S. University Drive, Fort Worth, 76129 TX USA.
Hana M DobrovolnyDepartment of Physics and Astronomy, Texas Christian University, 2800 S. University Drive, Fort Worth, 76129 TX USA.ORCID 0000-0003-3592-6770

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the primary cancer treatment modalities is chemotherapy. Unfortunately, traditional anti-cancer drugs are often not selective and cause damage to healthy cells, leading to serious side effects for patients. For this reason more targeted therapeutics and drug delivery methods are being developed. The effectiveness of new treatments is initially determined via in vitro cell viability assays, which determine the

Indexed as

ChemotherapyData fittingDrug efficacyMathematical modelParameter estimation

Identifiers

PMID34926126
PMCPMC8645675

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.