Evidence map›Paper›PMID 34925989›Full record

ArticleCureus2021

Exacerbation of Secondary Cold Agglutinin Syndrome in the Setting of SARS-CoV-2.

Yash V Bhagat, Siham Hussien, Helen Queenan, Miriam B Michael

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Yash V BhagatInternal Medicine, University of Maryland Midtown Campus, Baltimore, USA.
Siham HussienInternal Medicine, University of Maryland Midtown Campus, Baltimore, USA.
Helen QueenanInternal Medicine, Howard University College of Medicine, Washington, D.C., USA.
Miriam B MichaelInternal Medicine, Howard University College of Medicine, Washington, D.C., USA.
American University of Antigua · AGHoward University · USUniversity of Maryland, Baltimore · USUniversity of Maryland Medical Center Midtown Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this report, we present a case of exacerbation of cold agglutinin syndrome (CAS) potentially due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. An 83-year-old female with a history of cold agglutinin hemolytic anemia presented with shortness of breath, productive cough, worsening orthopnea, darkening fingers and urine, and jaundice. Laboratory investigations found elevated white blood cells (WBC) and total bilirubin, severely low hemoglobin, and positive direct Coombs test. Moreover, SARS-CoV-2 RNA was also found to be positive in a sample from the nasal swab by reverse transcription-polymerase chain reaction (RT-PCR), indicating exacerbation of CAS secondary to viral coronavirus 2019 (COVID-19) infection. A treatment regime for SARS-CoV-2 consisting of five days of remdesivir and seven days of dexamethasone 6 mg IV was initiated, resulting in significant improvement in the patient's condition.

Indexed as

autoimmune hemolytic anemia (aiha)cold agglutinin syndromecovid-19covid-19 associated coagulopathycovid-19 pneumoniacovid coagulopathycovid hypercoagulabilitysars-cov-2severe acute respiratory syndrome coronavirus-2 (sars-cov-2)transfusion in covid 19 pandemic

Identifiers

PMID34925989
PMCPMC8655486
OpenAlexW3214581924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.