Evidence map›Paper›PMID 34925569›Full record

ArticleActa endocrinologica (Bucharest, Romania : 2005)

INCIDENTAL PARATHYROIDECTOMY DURING TOTAL THYROIDECTOMY AS A POSSIBLE RISK FACTOR OF HYPOCALCEMIA. EXPERIENCE OF A SINGLE CENTER AND REVIEW OF LITERATURE.

E Spaziani, A R Di Filippo, C Di Cristofano, G Caruso, M Spaziani, S Orelli, F Fiorini, M Picchio, A De Cesare

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Factors affecting the rates of incidental parathyroidectomy during thyroidectomy.Annals of the Royal College of Surgeons of England · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

E Spaziani"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy.
A R Di Filippo"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy.
C Di Cristofano"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy.
G Caruso"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy.
M Spaziani"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy.
S Orelli"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Radiological, Oncological and Anatomo-Pathological Sciences, Latina, Rome, Italy.
F Fiorini"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy.
M PicchioASL Roma 6 "P. Colombo" Hospital - Division of Surgery, Rome, Italy.
A De Cesare"La Sapienza" University of Rome, Faculty of Pharmacy and Medicine - Department of Surgery, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPost-operative clinical and biochemical hypocalcemia is a common complication of thyroid surgery and the correlation with incidental parathyroidectomy (IP) remains controversial.

objectiveTo evaluate the incidence of IP during TT, its correlation to early post-surgery hypocalcemia, and its potential risk factors. PATIENTS AND

methods77 consecutive patients submitted to thyroid surgery between January 2018 and December 2019. Demographic, clinical, biochemical, surgical and histopathological factors were assessed. Statistical multivariate analysis was performed to identify the risk of IP.

resultsIP was evident in 22 (28.5%) patients who underwent TT, TT with lymph node dissection of the central compartment (CLND) and reoperation for previous hemithyroidectomy with CLND. Early symptomatic hypocalcemia 24 hours after TT was demonstrated in 12/22 (54.5%) patients, with PTH value of <14pg/mL in 7/12 (58.3%) patients, and in 6 of these 7 patients (85.7%) the PTH value was <6.3pg/mL. In 5/22 (22.7%) patients the IP was associated with biochemical hypocalcemia <8.4mg/dL, and in 5/22 (22.7%) patients anatomical damage was not associated with a reduction in plasma calcium levels. The severity of early post-op hypocalcemia was not correlated with the number of parathyroid glands left

conclusionsNo IP clinical-pathological risk factors have been identified during thyroid surgery. In all cases of TT, with or without CLND, the meticulous identification of the parathyroid glands, whose incidental removal is frequently associated with clinical and biochemical hypocalcemia, is recommended.

Indexed as

HypocalcemiaIncidental ParathyroidectomyThyroidectomy

Identifiers

PMID34925569
PMCPMC8665250
OpenAlexW4200111530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.