Evidence map›Paper›PMID 34925549›Full record

ArticleChild development perspectives2021

The Pubertal Stress Recalibration Hypothesis: Potential Neural and Behavioral Consequences.

Carrie E DePasquale, Max P Herzberg, Megan R Gunnar

Abstract read
In one paragraph

Article in Child development perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Hypothalamic-Pituitary-Adrenal Axis Recalibration During Puberty Among Maltreated Youth: The Role of Caregiver Depression.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
    Article
  8. Review
  9. Article
  10. Attachment orientation and platelet activity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Article
  11. Article
  12. The epigenetic impacts of pubertal acceleration following early caregiver disruptions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Measuring neuroplasticity in human development: the potential to inform the type and timing of mental health interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carrie E DePasqualeUniversity of Minnesota.ORCID 0000-0003-4812-3766
Max P HerzbergWashington University School of Medicine.ORCID 0000-0003-3177-7966
Megan R GunnarUniversity of Minnesota.ORCID 0000-0003-2296-9739

Funding

INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32MH015755 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Megan R Gunnar · 1985 to 2026
$5.9M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Social Buffering Over the Pubertal Transition: COVID-19 Repair SupplementR01HD095904 · NICHD · UNIVERSITY OF MINNESOTA · PI GUNNAR, MEGAN R, THOMAS, KATHLEEN M · 2019 to 2024
$3.3M
NRSA Training CoreTL1TR002493 · NCATS · UNIVERSITY OF MINNESOTA · PI FULKERSON, JAYNE ALLYN · 2018 to 2022
$3.1M
NCATS NIH HHS TL1 TR002493NICHD NIH HHS R01 HD095904NIMH NIH HHS T32 MH015755NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

Recent research has suggested that the pubertal period provides an opportunity for recalibrating the stress-responsive systems in youth whose responses to stress have been altered by early adversity. Such recalibration may have cascading effects that affect brain and behavioral development. In this article, we consider a large, cross-species literature to demonstrate the potential importance of pubertal stress recalibration for understanding the development of psychopathology following early deprivation by caregivers. We review the evidence for recalibration of the hypothalamic-pituitary-adrenal axis in humans, examine research on rodents that has established mechanisms through which stress hormones affect brain structure and function, and summarize the literature on human neuroimaging to assess how these mechanisms may translate into changes in human behavior. Finally, we suggest ideas for elucidating the consequences of pubertal stress recalibration that will improve our understanding of adaptive and maladaptive adolescent behavior following early adversity.

Indexed as

cortisolearly life stresspubertal stress recalibration

Identifiers

PMID34925549
PMCPMC8680280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.