Evidence map›Paper›PMID 34925539›Full record

Observational studyComputational and mathematical methods in medicine2021

Neoadjuvant Chemotherapy plus Bevacizumab Combined with Total Mesorectal Excision in Treating Locally Advanced Rectal Cancer Patients with BRAF Mutation: Clinical Benefit and Safety.

Jintian Song, Yi Wang, Hui Yu, Liang Zheng, Xiongchao Cai, Yigui Chen

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jintian Song *Department of Abdominal Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou City, Fujian Province 350014, China.ORCID https://orcid.org/0000-0003-0369-686X
Yi Wang *Department of Abdominal Tumor Surgery, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou City, Fujian Province 350014, China.ORCID https://orcid.org/0000-0001-7496-8901
Hui YuDepartment of Pharmacy, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou City, Fujian Province 350014, China.ORCID https://orcid.org/0000-0001-5257-4071
Liang ZhengDepartment of Abdominal Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou City, Fujian Province 350014, China.ORCID https://orcid.org/0000-0001-5996-4945
Xiongchao CaiDepartment of Abdominal Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou City, Fujian Province 350014, China.ORCID https://orcid.org/0000-0001-5462-1564
Yigui ChenDepartment of Abdominal Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou City, Fujian Province 350014, China.ORCID https://orcid.org/0000-0001-6488-5010
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate clinical benefit and safety of neoadjuvant chemotherapy (NAC) plus bevacizumab combined with total mesorectal excision (TME) in treating patients with BRAF-mutated locally advanced rectal cancer (LARC).

methodsThis study included LARC patients with BRAF mutation admitted to the Oncology Department of Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, between June 2013 and December 2018. Patients in the control group received a standard treatment regimen of TME combined with NAC (

resultsCompared with the control group, the ypT staging rate (

conclusionCompared with TME plus NAC treatment, the short-term and long-term clinical benefits are higher and safety is more favorable of NAC plus bevacizumab combined with TME in treating LARC patients.

Indexed as

MutationNeoadjuvant TherapyAgedAntineoplastic Agents, ImmunologicalBevacizumabComputational BiologyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedProto-Oncogene Proteins B-rafRectal NeoplasmsTreatment OutcomeAntineoplastic Agents, ImmunologicalBevacizumabBRAF protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID34925539
PMCPMC8677386
OpenAlexW4200206495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.