Evidence map›Paper›PMID 34925524›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes.

Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cui

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bo YangDepartment of Orthopedic Surgery, Shanghai TCM-Integrated Hospital Shanghai University of TCM, No. 230, Baoding Road, Hongkou, Shanghai, China.
Haisheng HuangDepartment of Orthopedic Surgery, Shanghai TCM-Integrated Hospital Shanghai University of TCM, No. 230, Baoding Road, Hongkou, Shanghai, China.
Qisong HeDepartment of Orthopedic Surgery, Shanghai TCM-Integrated Hospital Shanghai University of TCM, No. 230, Baoding Road, Hongkou, Shanghai, China.
Wei LuDepartment of Orthopedic Surgery, Shanghai TCM-Integrated Hospital Shanghai University of TCM, No. 230, Baoding Road, Hongkou, Shanghai, China.
Lu ZhengDepartment of Orthopedic Surgery, Shanghai TCM-Integrated Hospital Shanghai University of TCM, No. 230, Baoding Road, Hongkou, Shanghai, China.
Li CuiDepartment of Acupuncture, Shanghai TCM-Integrated Hospital Shanghai University of TCM, No. 230, Baoding Road, Hongkou, Shanghai, China.ORCID https://orcid.org/0000-0002-1989-6682
Shanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress-induced chondrocyte apoptosis and degradation of the extracellular matrix (ECM) play an important role in the progression of osteoarthritis (OA). In addition, tert-butylhydroquinone (TBHQ) is an activator of the nuclear factor erythroid derived-2-related factor 2 (Nrf2). The present study aimed to determine the effectiveness of TBHQ in preventing the apoptosis of chondrocytes and degradation of the extracellular matrix, induced by oxidative stress, in vitro. Therefore, rat chondrocytes were exposed to 20

Identifiers

PMID34925524
PMCPMC8674040
OpenAlexW4200021836

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.