Evidence map›Paper›PMID 34925465›Full record

ArticleFrontiers in genetics2021

Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma.

Susu Zheng, Xiaoying Xie, Xinkun Guo, Yanfang Wu, Guobin Chen, Xiaochun Chen, Meixia Wang, Tongchun Xue, Boheng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Susu ZhengDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Xiaoying XieDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Xinkun GuoDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Yanfang WuDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Guobin ChenDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Xiaochun ChenDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Meixia WangDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Tongchun XueKey Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, Zhongshan Hospital and Shanghai Medical School, The Liver Cancer Institute, Fudan University, Shanghai, China.
Boheng ZhangDepartment of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
Fudan University · CNZhongshan Hospital · CNZhongshan Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis is a novel kind of cellular necrosis and shown to be involved in cancer progression. However, the diverse expression, prognosis and associations with immune status of pyroptosis-related genes in Hepatocellular carcinoma (HCC) have yet to be analyzed. Herein, the expression profiles and corresponding clinical characteristics of HCC samples were collected from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Then a pyroptosis-related gene signature was built by applying the least absolute shrinkage and selection operator (LASSO) Cox regression model from the TCGA cohort, while the GEO datasets were applied for verification. Twenty-four pyroptosis-related genes were found to be differentially expressed between HCC and normal samples. A five pyroptosis-related gene signature (GSDME, CASP8, SCAF11, NOD2, CASP6) was constructed according to LASSO Cox regression model. Patients in the low-risk group had better survival rates than those in the high-risk group. The risk score was proved to be an independent prognostic factor for overall survival (OS). The risk score correlated with immune infiltrations and immunotherapy responses. GSEA indicated that endocytosis, ubiquitin mediated proteolysis and regulation of autophagy were enriched in the high-risk group, while drug metabolism cytochrome P450 and tryptophan metabolism were enriched in the low-risk group. In conclusion, our pyroptosis-related gene signature can be used for survival prediction and may also predict the response of immunotherapy.

Indexed as

hepatocellular carcinomaimmune checkpoint inhibitorsimmune infiltratesprognosispyroptosis

Identifiers

PMID34925465
PMCPMC8678488
OpenAlexW3215390014

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.