Evidence map›Paper›PMID 34925356›Full record

ArticleFrontiers in immunology2021

Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages.

Su Zhang, Yaya Liu, Xuefeng Zhou, Min Ou, Guohui Xiao, Fang Li, Zhongyuan Wang, Zhaoqin Wang, Lei Liu, Guoliang Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Host-directed therapy for tuberculosis.European journal of medical research · 2025
    Review
  4. Review
  5. Immune and Metabolic Mechanisms of Endothelial Dysfunction.International journal of molecular sciences · 2024
    Review
  6. Targeting Macrophages: Therapeutic Approaches in Diabetic Kidney Disease.International journal of molecular sciences · 2024
    Review
  7. Myeloid-Specific SIRT6 Deletion Protects Against Particulate Matter (PMInternational journal of chronic obstructive pulmonary disease · 2023
    Article
  8. Review
  9. Frontiers in cellular and infection microbiology · 2023
    Review
  10. Article
  11. Review
  12. Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Su ZhangNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Yaya LiuDepartment of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Xuefeng ZhouSchool of Medical Technology, Guangdong Medical University, Dongguan, China.
Min OuNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Guohui XiaoNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Fang LiNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Zhongyuan WangNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Zhaoqin WangNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Lei LiuNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Guoliang ZhangNational Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Southern University of Science and Technology · CNShenzhen Third People’s Hospital · CNGuangdong Medical College · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The host immune system plays a pivotal role in the containment of

Indexed as

ApoptosisPhagocytosisAnimalsAntitubercular AgentsBacterial LoadHost-Pathogen InteractionsMacrophagesMiceMycobacterium tuberculosisNitric OxideNitric Oxide DonorsRAW 264.7 CellsSignal TransductionSirtuinsS-Nitroso-N-AcetylpenicillamineTuberculosisAntitubercular AgentsNitric OxideNitric Oxide DonorsSirt7 protein, mouseSirtuinsS-Nitroso-N-AcetylpenicillamineapoptosismacrophagesMycobacterium tuberculosisnitric oxideSIRT7

Identifiers

PMID34925356
PMCPMC8678072
OpenAlexW4200347617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.