Evidence map›Paper›PMID 34925312›Full record

ArticleFrontiers in immunology2021

Adoptive Cell Transfer of Allogeneic Epstein-Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report.

Bjoern-Thore Hansen, Petra Bacher, Britta Eiz-Vesper, Steffen M Heckl, Wolfram Klapper, Karoline Koch, Britta Maecker-Kolhoff, Claudia D Baldus, Lars Fransecky

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bjoern-Thore HansenMedical Department II - Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.
Petra BacherInstitute of Immunology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Britta Eiz-VesperInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Steffen M HecklMedical Department II - Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.
Wolfram KlapperSection for Hematopathology and Lymph Node Registry, Department of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany.
Karoline KochSection for Hematopathology and Lymph Node Registry, Department of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany.
Britta Maecker-KolhoffDepartment of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Claudia D BaldusMedical Department II - Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.
Lars FranseckyMedical Department II - Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.
University of Lübeck · DEMedizinische Hochschule Hannover · DEKiel University · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posttransplant smooth muscle tumors (PTSMTs) are rare Epstein-Barr virus (EBV)-associated neoplasms, mostly occurring after solid organ transplantation. Current therapeutic strategies include surgery and reduction of immunosuppressive medication. We describe for the first time a novel treatment approach for PTSMT by adoptive cell transfer (ACT) of EBV-specific T cells to a 20-year-old patient with a medical history of cardiac transplantation, posttransplant lymphoproliferative disease, and multilocular PTSMT. During ACT, mild cytokine release syndrome occurred, while no unexpected safety signals were recorded. We observed

Indexed as

Adoptive TransferAllogeneic CellsEpstein-Barr Virus InfectionsFemaleHeart TransplantationHerpesvirus 4, HumanHumansLymphoproliferative DisordersSmooth Muscle TumorT-LymphocytesTransplantation, HomologousTreatment OutcomeViremiaYoung Adultadoptive cell transferalloCELLcase reportposttransplant smooth muscle tumorsPTSMTsmooth muscle tumorT-cell transfervirus-specific T cells

Identifiers

PMID34925312
PMCPMC8677671
OpenAlexW4200324788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.