Evidence map›Paper›PMID 34925289›Full record

ArticleFrontiers in microbiology2021

Survival Comes at a Cost: A Coevolution of Phage and Its Host Leads to Phage Resistance and Antibiotic Sensitivity of

Sarshad Koderi Valappil, Prateek Shetty, Zoltán Deim, Gabriella Terhes, Edit Urbán, Sándor Váczi, Roland Patai, Tamás Polgár, Botond Zsombor Pertics, György Schneider and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Isolation and Genomic Characterization of LyticLife (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Review
  7. Understanding phage Receptor-binding protein interaction with host surface receptor: the key for phage-Mediated detection and elimination of Pseudomonas aeruginosa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  8. Article
  9. Review
  10. Synergistic Biocontrol ofInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Detection of the ST111 Global High-RiskCurrent issues in molecular biology · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Sarshad Koderi ValappilDepartment of Biotechnology, University of Szeged, Szeged, Hungary.
Prateek ShettyInstitute of Plant Biology, Biological Research Center, Szeged, Hungary.
Zoltán DeimDepartment of Biotechnology, University of Szeged, Szeged, Hungary.
Gabriella TerhesDepartment of Clinical Microbiology, University of Szeged, Szeged, Hungary.
Edit UrbánDepartment of Clinical Microbiology, University of Szeged, Szeged, Hungary.
Sándor VácziDepartment of Pathophysiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Roland PataiInstitute of Biophysics, Biological Research Center, Szeged, Hungary.
Tamás PolgárInstitute of Biophysics, Biological Research Center, Szeged, Hungary.
Botond Zsombor PerticsDepartment of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.
György SchneiderDepartment of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.
Tamás KovácsDepartment of Biotechnology, Nanophagetherapy Center, Enviroinvest Corp., Pécs, Hungary.
Gábor RákhelyDepartment of Biotechnology, University of Szeged, Szeged, Hungary.
University of Szeged · HUInstitute of Biophysics · HUUniversity of Pecs · HUEnviroinvest Environmental and Biotechnological Corp · HUInstitute of Plant Biology · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing ineffectiveness of traditional antibiotics and the rise of multidrug resistant (MDR) bacteria have necessitated the revival of bacteriophage (phage) therapy. However, bacteria might also evolve resistance against phages. Phages and their bacterial hosts coexist in nature, resulting in a continuous coevolutionary competition for survival. We have isolated several clinical strains of

Indexed as

bacteriophage therapycombined treatmentMexXY-OprM efflux systemphage-provoked sequential genomic mutation/deletionphage resistance

Identifiers

PMID34925289
PMCPMC8678094
OpenAlexW3217233381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.