ArticleFrontiers in endocrinology2021
Attenuation Value in Adrenal Incidentalomas: A Longitudinal Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Adrenalectomy Improves Blood Pressure and Metabolic Control in Patients With Possible Autonomous Cortisol Secretion: Results of a RCT.Frontiers in endocrinology · 2022Trial
- Progression of bilateral adrenal incidentalomas: a monocentric cohort study.Frontiers in endocrinology · 2026Article
- Review
- Washed up: the end of an era for adrenal incidentaloma CT.Insights into imaging · 2025Review
- Could CT Radiomic Analysis of Benign Adrenal Incidentalomas Suggest the Need for Further Endocrinological Evaluation?Current oncology (Toronto, Ont.) · 2024Article
- Clinical Evaluation of Adrenal Incidentaloma: The Experience of a Referral Center.Biomedicines · 2024Article
- Clinical and imaging presentations are associated with function in incidental adrenocortical adenomas: a retrospective cohort study.European journal of endocrinology · 2024Article
- Tumor enlargement in adrenal incidentaloma is related to glaucoma: a new prognostic feature?Journal of endocrinological investigation · 2024Article
- Are comorbidities of patients with adrenal incidentaloma tied to sex?Frontiers in endocrinology · 2024Article
- Can MDCT Enhancement Patterns Be Helpful in Differentiating Secretory from Non-Functional Adrenal Adenoma?Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Stress-induced severe transient hypercortisolism with reversible bilateral adrenal enlargement after cardiogenic shock.Endocrinology, diabetes & metabolism case reports · 2023Article
- CT Texture Analysis of Adrenal Pheochromocytomas: A Pilot Study.Current oncology (Toronto, Ont.) · 2023Article
- Editorial: A year in review: discussions in adrenal endocrinology.Frontiers in endocrinology · 2023Article
- Predicting morphological and functional variations of benign adrenal incidentalomas in relation to initial characteristics.Frontiers in endocrinology · 2023Review
- Adrenal Lesions: A Review of Imaging.Diagnostics (Basel, Switzerland) · 2022Review
- Differential diagnostic value of plain CT scan in adrenal adenoma and non-adenoma: A two-center control study of mean attenuation value, minimum attenuation value, and CT histogram.Frontiers in endocrinology · 2022Article
- Computed Tomography-Based Machine Learning Differentiates Adrenal Pheochromocytoma From Lipid-Poor Adenoma.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: A tendency to grow has been reported in adrenal incidentalomas. However, long-term data regarding attenuation value, a measure of lipid content, are not available. Aim: This study aims to collect radiological data (diameter in mm and attenuation value in Hounsfield units, HU) with computed tomography (CT) in adrenal incidentalomas, in order to compare baseline characteristics with the last follow-up imaging. Design: This is a longitudinal study which included patients with a new diagnosis of adrenal incidentaloma, evaluated from January 2002 to June 2020. Setting: Referral University-Hospital center. Patients: Two hundred seventy-seven patients with 355 different cortical adenomas (baseline group) were evaluated at the first outpatient visit; the follow-up cohort consists of 181 patients with 234 adenomas (12-175 months after baseline). Inclusion criteria were conservative management and radiological features able to minimize malignancy or risk of progression. Main Outcome Measure: CT modification according to endocrine function: autonomous cortisol secretion (ACS) if cortisol >50 nmol/L after 1-mg dexamethasone test (DST). Results: At baseline CT, mean diameter was 18.7 mm and attenuation value was 0.8 HU (higher in ACS, 66 cases >10 HU), without modification in early imaging (12-36 months). The size increased over time ( Conclusions: Growth is clinically modest in adrenal incidentaloma: the first follow-up CT 5 years after baseline is a reasonable choice, especially in ACS. Mean density is increased in patients with ACS and overt hypercortisolism. Mean density reduces during follow-up in all adrenal adenomas, suggesting an increase in lipid content, especially in those with ACS.
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Registered trials
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