ArticleFrontiers in endocrinology2021
Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Recent advances in research on the association between paediatric hyperuricaemia and bone health.Frontiers in endocrinology · 2026Pooled it
- The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Body Weight and Insulin Resistance Indicators Among Children.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Novel epigenetic marks of insulin resistance trajectories in a longitudinal study of childhood obesity.Cardiovascular diabetology · 2026Article
- Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways.Endocrinology, diabetes & metabolism · 2026Review
- Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications.Frontiers in endocrinology · 2026Review
- Retinol Binding Protein 4 and Uric Acid as Risk Factors for Insulin Resistance in Type 2 Diabetes Mellitus.Journal of diabetes research · 2026Article
- Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Comparison of different insulin resistance surrogates in predicting hyperuricemia in non-diabetic Yi residents in Yunnan Province.Frontiers in endocrinology · 2025Article
- Association Between Hyperuricemia, Body Composition, and Comorbidities in an Obese Pediatric Population.Journal of nutrition and metabolism · 2025Article
- Correlation Analysis between Serum Uric Acid Levels and Bone Mineral Density in Children with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The associations of insulin resistance, obesity, and lifestyle with the risk of developing hyperuricaemia in adolescents.BMC endocrine disorders · 2024Article
- Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents.European journal of clinical nutrition · 2024Article
- Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and insulin resistance in an American population: A population-based analysis.Journal of diabetes investigation · 2024Article
- The Association of Serum Uric Acid Levels and Various Uric Acid-Related Ratios with Insulin Resistance and Obesity: A Preliminary Study in Adolescents.Children (Basel, Switzerland) · 2023Article
- Characteristics of Children and Adolescents with Hyperinsulinemia Undergoing Oral Glucose Tolerance Test: A Single-Center Retrospective Observational Study.Diseases (Basel, Switzerland) · 2023Article
- Salivary uric acid across child development and associations with weight, height, and body mass index.Frontiers in pediatrics · 2023Article
- The Relationship between Anthropometric Measurements and Vitamin D Levels and Insulin Resistance in Obese Children and Adolescents.Children (Basel, Switzerland) · 2022Article
- Obesity, Diabetes Mellitus, and Vascular Impediment as Consequences of Excess Processed Food Consumption.Cureus · 2022Review
- Global disease burden of stroke attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2019: An analysis of the Global Burden of Disease Study.Journal of diabetes · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents. Methods: A total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 to January 2019 were recruited for this retrospective study. We classified participants into two groups on the basis of HOMA-IR values: the low HOMA-IR group (< 3.16) (n = 222) and the high HOMA-IR group (≥ 3.16) (n = 147). Results: The univariate analysis found that the high HOMA-IR group had higher BMI, SUA, and fasting insulin (FINS) ( Conclusions: SUA should be investigated in obesity and plays a partial mediating role in insulin resistance induced by obesity in obese children and adolescents.
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Registered trials
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