Evidence map›Paper›PMID 34925235›Full record

ArticleFrontiers in endocrinology2021

Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling.

Uchechukwu T Agwuegbo, Emily Colley, Anthony P Albert, Viktor Y Butnev, George R Bousfield, Kim C Jonas

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

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  13. Human FSH Glycoform α-Subunit AsparagineFrontiers in endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Uchechukwu T AgwuegboSchool of Life Course and Population Sciences, Department of Women and Children's Health, Guy's Campus, King's College London, London, United Kingdom.
Emily ColleyInstitute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom.
Anthony P AlbertVascular Biology Research Centre, Molecular & Clinical Science Research Centre, St George's University of London, London, United Kingdom.
Viktor Y ButnevDepartment of Biological Sciences, Wichita State University, Wichita, KS, United States.
George R BousfieldDepartment of Biological Sciences, Wichita State University, Wichita, KS, United States.
Kim C JonasSchool of Life Course and Population Sciences, Department of Women and Children's Health, Guy's Campus, King's College London, London, United Kingdom.
King's College London · GBWichita State University · USImperial College London · GBSt George's, University of London · GB

Funding

The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI CHITTIBABU GUDA · 2009 to 2026
$25.9M
Biotechnology and Biological Sciences Research Council BB/R015961/1Biotechnology and Biological Sciences Research Council BB/R015961/2NIA NIH HHS P01 AG029531
6 · The paper itself

Abstract

Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive

Indexed as

Cell LineFollicle Stimulating HormoneGlycosylationHEK293 CellsHumansReceptors, FSHSignal TransductionFollicle Stimulating HormoneReceptors, FSHfollicle-stimulating hormonefollicle-stimulating hormone receptorgonadotropic hormonesG protein-coupled receptors (GPCR)oligomerizationoligomers

Identifiers

PMID34925235
PMCPMC8678890
OpenAlexW4200583091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.