Evidence map›Paper›PMID 34925231›Full record

ArticleFrontiers in endocrinology2021

Deciphering the Irregular Risk of Stroke Increased by Obesity Classes: A Stratified Mendelian Randomization Study.

Xuelun Zou, Leiyun Wang, Linxiao Xiao, Zihao Xu, Tianxing Yao, Minxue Shen, Yi Zeng, Le Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xuelun ZouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Leiyun WangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Linxiao XiaoDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Zihao XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Tianxing YaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Minxue ShenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Yi ZengDepartment of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, China.
Le ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To investigate the relationship between different classes of obesity and stroke, we conducted a stratified Mendelian randomization (MR) study. Methods: The body mass index (BMI) data of 263,407 Europeans with three classes of obesity (obesity class I, 30 kg/m Results: The MR analysis revealed that both obesity class I [odds ratio (OR) = 1.08, 95% CI: 1.05-1.12, Conclusions: A higher risk of IS, but not ICH, could be linked to obesity classes I and II. A strong association between LAS and CES and obesity was observed among all IS subtypes in the obese population.

Indexed as

AdultAgedBody Mass IndexEuropeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracranial HemorrhagesIschemic StrokeMaleMendelian Randomization AnalysisMiddle AgedObesityObesity, MorbidPolymorphism, Single Nucleotidebody mass indexgenome-wide association studyMendelian randomizationobesitystroke

Identifiers

PMID34925231
PMCPMC8671740
OpenAlexW3216101874

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.