Evidence map›Paper›PMID 34925230›Full record

ArticleFrontiers in endocrinology2021

The Role of Estrogen Receptor α in Response to Longitudinal Bone Growth in ob/ob Mice.

Lin-Yu Jin, Chen Guo, Shuai Xu, Hai-Ying Liu, Xin-Feng Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Crosstalk between bone and other organs.Medical review (2021) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lin-Yu JinDepartment of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, China.
Chen GuoDepartment of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, China.
Shuai XuDepartment of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, China.
Hai-Ying LiuDepartment of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, China.
Xin-Feng LiDepartment of Spinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Peking University People's Hospital · CNPeking University · CNRenji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The absence of leptin results in contrasting growth pattern of appendicular and axial bone growth in ob/ob mice. Endochondral bone formation is an important procedure of growth plate determining the bone growth, where this procedure is also regulated by estrogen and its receptor (ER) signaling pathway. The present study is undertaken to explore the roles of ERs in regulating the different growth patterns in ob/ob mice. In this study, C57BL/6 female mice were used as wild-type (WT) mice; ob/ob mice and WT mice were age-matched fed, and bone length is analyzed by X-ray plain film at the 12 weeks old. We confirm that ob/ob mice have shorter femoral length and longer spine length than WT mice (

Indexed as

AnimalsApoptosisBone DevelopmentEstrogen Receptor alphaEstrogen Receptor ModulatorsFemurMiceMice, ObesePiperidinesPyrazolesPyrimidines1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenolEstrogen Receptor alphaEstrogen Receptor ModulatorsPiperidinesPyrazolesPyrimidinesendochondral bone formationestrogen receptorgrowth plateleptinskeletal longitudinal growth

Identifiers

PMID34925230
PMCPMC8671758
OpenAlexW3216253360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.