ArticleFrontiers in endocrinology2021
A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- An early LH surge may jeopardize ART outcomes of patients with PCOS and its predictive models.Reproduction & fertility · 2026Article
- Monoclonal antibody potentiating gonadotropin activity in vitro and in vivo in male and female rats and in ewes.Reproduction (Cambridge, England) · 2025Article
- Article
- Clomiphene citrate reduces premature LH surge in obese women during controlled ovarian stimulation: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Serum luteinizing hormone trajectories during ovarian stimulation and their outcomes of IVF/ICSI: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Effect of LH level on HCG trigger day on clinical outcomes in patients with diminished ovarian reserve undergoing GnRH-antagonist protocol.Reproductive biology and endocrinology : RB&E · 2024Article
- Impact of stimulation with luteinizing hormone activity on IVF outcomes in patients with polycystic ovary syndrome.Journal of the Turkish German Gynecological Association · 2024Article
- Predicting personalized cumulative live birth rate after a complete in vitro fertilization cycle: an analysis of 32,306 treatment cycles in China.Reproductive biology and endocrinology : RB&E · 2024Article
- Effect of premature luteinizing hormone surge on pregnancy outcomes in intracytoplasmic sperm injection orFrontiers in medicine · 2024Article
- Optimal timing of GnRH antagonist initiation in IVF-ET: a retrospective cohort study on advanced maternal age women.Frontiers in endocrinology · 2024Article
- Reproductive outcomes in fresh transfer cycles and antagonists with premature luteinizing and/or progesterone surge: a single center retrospective cohort study.Frontiers in endocrinology · 2024Article
- A premature luteinizing hormone surge without elevated progesterone levels has no adverse effect on cumulative live birth rate in patient undergoing a flexible GnRH antagonist protocol: a retrospective study.Journal of ovarian research · 2023Article
- The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles.Journal of clinical medicine · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is a retrospective cohort study included 1021 patients underwent a flexible GnRH antagonist IVF protocol from January 2017 to December 2017 to explore the effect of a premature rise in luteinizing hormone (LH) level on the cumulative live birth rate. All patients included received the first ovarian stimulation and finished a follow-up for 3 years. A premature rise in LH was defined as an LH level >10 IU/L or >50% rise from baseline during ovarian stimulation. The cumulative live birth rate was calculated as the number of women who achieved a live birth divided by the total number of women who had either delivered a baby or had used up all their embryos received from the first stimulated cycle. In the advanced patients (≥37 years), the cumulative live birth rate was reduced in patients with a premature rise of LH (β: 0.20; 95% CI: 0.05-0.88;
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