Evidence map›Paper›PMID 34925180›Full record

ArticleFrontiers in psychology2021

What Matters Most in Life? A German Cohort Study on the Sources of Meaning and Their Neurobiological Foundations in Four Age Groups.

Christopher Karwetzky, Lena Werdecker, Tobias Esch

Abstract read
In one paragraph

Article in Frontiers in psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cancer patients' perceptions of the meaning in life: a qualitative meta-synthesis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  2. Meaning in Life Among Aged People: A Qualitative Study of an Institutionalized Elderly Sample.European journal of investigation in health, psychology and education · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher KarwetzkyFaculty of Health, Institute for Integrative Health Care and Health Promotion, Witten/Herdecke University, Witten, Germany.
Lena WerdeckerFaculty of Health, Institute for Integrative Health Care and Health Promotion, Witten/Herdecke University, Witten, Germany.
Tobias EschFaculty of Health, Institute for Integrative Health Care and Health Promotion, Witten/Herdecke University, Witten, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Existing work in the field of positive psychology suggests that people can draw meaning from a variety of sources. The present study aimed to identify the most important sources of meaning and to explore the role of age and neural adaptation processes in this context. As part of a large German cohort study, 1,587 individuals between 12 and 94 years were asked to provide a maximum of five responses to the question "What matters most to you in life?" We divided the study population into four age groups and analyzed the obtained answers qualitatively and quantitatively using (1) word clouds and (2) frequency comparisons based on a summarizing content analysis. A chi-squared test was used to test the observed differences between age groups. Identified sources of meaning could be clustered into 16 main and 76 subcategories, with

Indexed as

agingmeaningfulnessmotivationneurobiologysources of meaning

Identifiers

PMID34925180
PMCPMC8671042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.