Evidence map›Paper›PMID 34925070›Full record

ReviewFrontiers in physiology2021

Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells.

Isabella Marinelli, Patrick A Fletcher, Arthur S Sherman, Leslie S Satin, Richard Bertram

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. GABA Regulates CaMetabolites · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. KThe Journal of physiology · 2023
    Article
  7. Article
  8. Multilevel synchronization of humanFrontiers in network physiology · 2023
    Article
  9. Article
  10. Coordination of pancreatic islet rhythmic activity by delayed negative feedback.American journal of physiology. Endocrinology and metabolism · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. The role of GABA in islet function.Frontiers in endocrinology · 2022
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Isabella MarinelliCentre for Systems Modelling and Quantitative Biomedicine (SMQB), University of Birmingham, Birmingham, United Kingdom.
Patrick A FletcherLaboratory of Biological Modeling, National Institutes of Health, Bethesda, MD, United States.
Arthur S ShermanLaboratory of Biological Modeling, National Institutes of Health, Bethesda, MD, United States.
Leslie S SatinDepartment of Pharmacology, Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, MI, United States.
Richard BertramPrograms in Neuroscience and Molecular Biophysics, Department of Mathematics, Florida State University, Tallahassee, FL, United States.
National Institutes of Health · USFlorida State University · USUniversity of Birmingham · GBUniversity of Michigan–Ann Arbor · US

Funding

METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023
$9.1M
NIDDK NIH HHS R01 DK046409
6 · The paper itself

Abstract

Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by pulses of elevated intracellular Ca

Indexed as

burstingcalciuminsulinmetabolismoscillations

Identifiers

PMID34925070
PMCPMC8682964
OpenAlexW4200106504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.