Evidence map›Paper›PMID 34925041›Full record

ArticleFrontiers in pharmacology2021

Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging.

Ni Zhang, Lichong Zhu, Qiuhong Ouyang, Saisai Yue, Yichun Huang, Shuang Qu, Runwei Li, Yuanyuan Qiao, Man Xu, Fangfei He and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Carbapenem-resistantFrontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Ni ZhangDepartment of Psychiatry, and Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
Lichong ZhuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Qiuhong OuyangDepartment of Psychiatry, and Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
Saisai YueCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Yichun HuangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Shuang QuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Runwei LiCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Yuanyuan QiaoCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Man XuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Fangfei HeCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Bin ZhaoXinxiang Key Laboratory of Forensic Toxicology, School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China.
Lai WeiXinxiang Key Laboratory of Forensic Toxicology, School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China.
Xiaoai WuDepartment of Psychiatry, and Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
Peisen ZhangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Beijing University of Chemical Technology · CNWest China Hospital of Sichuan University · CNXinxiang Medical University · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymyxin B (PMB) exert bactericidal effects on the cell wall of Gram-negative bacteria, leading to changes in the permeability of the cytoplasmic membrane and resulting in cell death, which is sensitive to the multi-resistant Gram-negative bacteria. However, the severe toxicity and adverse side effects largely hamper the clinical application of PMB. Although the molecular pathology of PMB neurotoxicity has been adequately studied at the cellular and molecular level. However, the impact of PMB on the physiological states of central nervous system

Indexed as

Fe3O4 nanoparticlesin vivoneurotoxicitypolymyxin Bsusceptibility-weighted imaging

Identifiers

PMID34925041
PMCPMC8675099
OpenAlexW3216267424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.