ReviewFrontiers in neuroscience2021
Psychobiological Consequences of Childhood Sexual Abuse: Current Knowledge and Clinical Implications.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Health behaviours and telomere biology in severe mental disorders.Translational psychiatry · 2026Article
- Childhood Sexual Abuse and Rates of Loneliness in Adulthood.JAMA network open · 2026Article
- Work-life conflict, coaching, and workplace harassment as determinants of employee well-being.Scientific reports · 2026Article
- Dealing With Defilement Cases in Ghana: Intricacies of Law, Sociology and Psychology.Sexual offending (Trier, Germany) · 2026Review
- Observational
- The effect of an educational program on knowledge about sexual abuse prevention among child laborers: a quasi-experimental study.BMC public health · 2025Article
- The Many Faces of Child Abuse: How Clinical, Genetic and Epigenetic Correlates Help Us See the Full Picture.Children (Basel, Switzerland) · 2025Review
- Childhood abuse and neglect are differentially related to perceived discrimination and structural change in empathy-related circuitry.Scientific reports · 2025Article
- Resilience amid Adversity: A Qualitative Narrative Study of Childhood Sexual Abuse Among Bangladeshi Transgender Individuals.International journal of environmental research and public health · 2025Article
- Examining the burden of mental disorders in Jordan: an ecological study over three decades.BMC psychiatry · 2025Article
- Piloting an Alternative Implementation Modality for a School-Based Child Sexual Abuse Prevention Curriculum.International journal of environmental research and public health · 2024Article
- Complex Intersections Between Adverse Childhood Experiences and Negative Life Events Impact the Phenome of Major Depression.Psychology research and behavior management · 2024Article
- The long-term impact of childhood sexual assault on depression and self-reported mental and physical health.Frontiers in psychiatry · 2024Article
- Review
- Creating the necessary infrastructure for a trauma-informed system of care for children and youth.Frontiers in psychology · 2023Article
- Sexual arousal after abuse: (Mal)adaptations of the local immune response.Brain, behavior, and immunity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large body of research has documented the long-term harms of childhood sexual abuse (CSA) on an individual's emotional-adaptive function and mental health. Recent studies have also provided evidence of the biological impact of CSA, implicating specific alterations in many systems, including the endocrine and immune systems, and in DNA and chromatin, in the pathogenesis of medical disorders. Although the effects of CSA are often examined with regard to the general impact of early-life traumatic experiences, the study of CSA per sè, as a trigger of specific pathogenic pathways, would be more appropriate to understand their long-term implications and develop tailored diagnostic and therapeutic strategies. Based on these premises, this narrative minireview summarizes the research on the short-term and long-term sequelae of CSA, focusing on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, the effects on the immune system, and the changes to DNA through altered methylation. Also, we discuss the literature that examines dysfunctional DNA telomere erosion and oxidative stress markers as a sign of CSA. Finally, recent evidence of the intergenerational transmission of the effects of CSA is reported. The impact of CSA on brain connectivity and functions is out of the scope of this review, thus brain imaging studies are not included. The results of this minireview are discussed, considering their implications for prevention and clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.