Evidence map›Paper›PMID 34924935›Full record

ArticleFrontiers in neuroscience2021

Synthesis and Evaluation of a Fluorine-18 Radioligand for Imaging Huntingtin Aggregates by Positron Emission Tomographic Imaging.

Tanpreet Kaur, Allen F Brooks, Alex Lapsys, Timothy J Desmond, Jenelle Stauff, Janna Arteaga, Wade P Winton, Peter J H Scott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Preclinical evaluation of the novel [European journal of nuclear medicine and molecular imaging · 2024
    Article
  4. Article
  5. A Positron Emission Tomography Ligand for Mutant Huntingtin Sheds Light on Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  6. Automated Synthesis ofFrontiers in chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tanpreet KaurDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Allen F BrooksDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Alex LapsysDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Timothy J DesmondDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Jenelle StauffDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Janna ArteagaDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Wade P WintonDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
Peter J H ScottDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Synthesis of Novel PET Radiotracers for Imaging in Alzheimer’s Disease and Related DisordersR01EB021155 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANFORD, MELANIE S., SCOTT, PETER JAMES HENRY · 2016 to 2024
$3.2M
NIBIB NIH HHS R01 EB021155
6 · The paper itself

Abstract

Mutations in the huntingtin gene (HTT) triggers aggregation of huntingtin protein (

Indexed as

[11C]CHDIfluorine-18Huntington’s diseasePET imagingradiotracer

Identifiers

PMID34924935
PMCPMC8675899
OpenAlexW4200466096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.