ArticleEpilepsy currents2021
Arousal and Consciousness in Focal Seizures.
Article in Epilepsy currents, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Does classical semiology ("5As") predict post-operative seizure outcome in patients with temporal lobe epilepsy?Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Bilateral ictal eye closure in focal epileptic seizures: SEEG retrospective observational assessment from a tertiary epilepsy center.Epileptic disorders : international epilepsy journal with videotape · 2026Observational
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures.Neurology · 2025Article
- Symptom network analysis of prefrontal seizures.Epilepsia · 2025Article
- Decreased locus coeruleus multiunit activity in a mouse model of temporal lobe seizures with impaired consciousness.Experimental neurology · 2025Article
- The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome.Nature communications · 2025Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.NeuroImage · 2025Article
- The thalamus: Structure, function, and neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks.Scientific reports · 2025Article
- Article
- Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness.Cell reports · 2024Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.bioRxiv : the preprint server for biology · 2024Article
- Localization of hypnopompic seizures - A stereo EEG study.Epilepsy & behavior reports · 2024Article
- Content-state dimensions characterize different types of neuronal markers of consciousness.Neuroscience of consciousness · 2024Article
- Article
- Review
- Progressive generalized tonic-clonic seizures in a transgenic mouse model of adult-onset epilepsy: Implications for morphological changes in cortico-limbic and brainstem structures.Epilepsy research · 2023Article
- Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testingEpileptic disorders : international epilepsy journal with videotape · 2022Article
- Sudden unexpected death in epilepsy.Current opinion in neurology · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Impaired consciousness during seizures severely affects quality of life for people with epilepsy but the mechanisms are just beginning to be understood. Consciousness is thought to involve large-scale brain networks, so it is puzzling that focal seizures often impair consciousness. Recent work investigating focal temporal lobe or limbic seizures in human patients and experimental animal models suggests that impaired consciousness is caused by active inhibition of subcortical arousal mechanisms. Focal limbic seizures exhibit decreased neuronal firing in brainstem, basal forebrain, and thalamic arousal networks, and cortical arousal can be restored when subcortical arousal circuits are stimulated during seizures. These findings open the possibility of restoring arousal and consciousness therapeutically during and following seizures by thalamic neurostimulation. When seizures cannot be stopped by existing treatments, targeted subcortical stimulation may improve arousal and consciousness, leading to improved safety and better psychosocial function for people with epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.