ArticleNoro psikiyatri arsivi2021
Evaluation of the Effect of Vortioxetine on Pain Threshold By Hot-Plate Test in Mice.
Article in Noro psikiyatri arsivi, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Protective Effects of PrenatalMolecules (Basel, Switzerland) · 2026Article
- The role of GABAergic receptors in acute, subacute, and withdrawal syndrome on pain and seizure thresholds in mice: A connection to mitochondrial function and oxidative stress in the brain.Toxicology reports · 2025Article
- Dexmedetomidine-Loaded Hydrogel Microneedles Alleviate Acute Inflammatory Visceral Pain in Mice.Gels (Basel, Switzerland) · 2025Article
- Synergistic Pain-Reducing Effects ofPharmaceuticals (Basel, Switzerland) · 2024Article
- German Chamomile (International journal of molecular sciences · 2024Article
- Article
- Vortioxetine treatment for neuropathic pain in major depressive disorder: a three-month prospective study.Frontiers in neurology · 2024Article
- Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain.Biomedicines · 2023Article
- Continuous release of mefloquine featured in electrospun fiber membranes alleviates epidural fibrosis and aids in sensory neurological function after lumbar laminectomy.Materials today. Bio · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVortioxetine is an antidepressant that has a multimadal action mechanism and has recently come into use. The present study was planned to determine whether vortioxetine affects pain threshold in mice.
methodThe experimental animals were divided into four groups with 10 mice in each group. The distilled water was given to the control group, 5 mg/kg of vortioxetine was intraperitoneally administered to the first group, 10 mg/kg of vortioxetine was intraperitoneally administered to the second group and 20 mg/kg of vortioxetine was intraperitoneally administered to the third group. Mice were placed on a hot-plate at 30 and 90 minutes. Hind paw licking and jumping times of the mice on the hot plate surface (55°C) were recorded..
resultsWith increasing dose (0 mg p>0.05, 5 mg p<0.001, 10 mg p<0.001, 20 mg p<0.001) and increasing time (30th minute p<0.01, 90th minute p<0.01), it was observed that the reaction time per minute, which was a reflection of pain treshold was decreased.
conclusionThe results of this study shows that vortioxetine may have a decreasing effect on pain threshold in mice. Further studies are needed to determine the mechanism by which vortioxetine exerts its hyperalgesic effect.
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