Evidence map›Paper›PMID 34924736›Full record

ArticlePolymers for advanced technologies2021

Grafting Polymer Brushes by ATRP from Functionalized Poly(ether ether ketone) Microparticles.

Liye Fu, Hossein Jafari, Michael Gießl, Saigopalakrishna S Yerneni, Mingkang Sun, Zongyu Wang, Tong Liu, Kriti Kapil, Boyle C Cheng, Alexander Yu and 2 more

Open access · greenAbstract read
In one paragraph

Article in Polymers for advanced technologies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Liye Fu *Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Hossein Jafari *Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Michael GießlDepartment of Chemistry, University of Konstanz, Universitatsstraße 10, D-78457 Konstanz, Germany.
Saigopalakrishna S YerneniDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Mingkang SunDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Zongyu WangDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Tong LiuDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Kriti KapilDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Boyle C ChengAllegheny Health Network - Neuroscience Institute, 320 E. North Avenue, Pittsburgh, Pennsylvania 15212, United States.
Alexander YuAllegheny Health Network - Neuroscience Institute, 320 E. North Avenue, Pittsburgh, Pennsylvania 15212, United States.
Saadyah E AverickAllegheny Health Network - Neuroscience Institute, 320 E. North Avenue, Pittsburgh, Pennsylvania 15212, United States.
Krzysztof MatyjaszewskiDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Carnegie Mellon University · USAllegheny Health Network · USUniversity of Konstanz · DE

Funding

Molecular pathogenesis of craniosynostosis caused by enhanced BMP signalingR01DE020843 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI · 2010 to 2019
$4.9M
Enhancing Osseointegration of PEEK with Straight Forward Chemical Derivation StrategyR21AR076525 · NIAMS · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI CHENG, BOYLE C. · 2020 to 2021
$387k
NIAMS NIH HHS R21 AR076525NIDCR NIH HHS R01 DE020843
6 · The paper itself

Abstract

Poly(ether ether ketone) (PEEK) is a semi-crystalline thermoplastic with excellent mechanical and chemical properties. PEEK exhibits a high degree of resistance to thermal, chemical, and bio-degradation. PEEK is used as biomaterial in the field of orthopaedic and dental implants; however, due to its intrinsic hydrophobicity and inert surface, PEEK does not effectively support bone growth. Therefore, new methods to modify PEEK's surface to improve osseointegration are key to next generation polymer implant materials. Unfortunately, PEEK is a challenging material to both modify and subsequently characterize thus stymieing efforts to improve PEEK osseointegration. In this manuscript, we demonstrate how surface-initiated atom transfer radical polymerization (SI-ATRP) can be used to modify novel PEEK microparticles (PMP). The hard core-soft shell microparticles were synthesized and characterized by DLS, ATR-IR, XPS and TEM, indicating the grafted materials increased solubility and stability in a range of solvents. The discovered surface grafted PMP can be used as compatibilizers for the polymer-tissue interface.

Identifiers

PMID34924736
PMCPMC8680496
OpenAlexW3167827565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.