Evidence map›Paper›PMID 34924726›Full record

ArticleJournal of orthopaedics

Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis.

Henry T Shu, Jacob D Mikula, Andrew T Yu, Babar Shafiq

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Arterial angioembolisation versus pre-peritoneal pelvic packing in haemodynamically unstable patients with complex pelvic fractures: a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Pooled it
  3. Pooled it
  4. Tranexamic acid in shoulder surgery: a narrative review.JSES reviews, reports, and techniques · 2026
    Review
  5. Article
  6. Preventing complications during acetabular fracture surgery, a review.Journal of clinical orthopaedics and trauma · 2025
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Henry T ShuDepartment of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Jacob D MikulaDepartment of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Andrew T YuDepartment of Neurology, The Johns Hopkins University, Baltimore, MD, USA.
Babar ShafiqDepartment of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery.

methodsFour studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients.

resultsThe transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02).

conclusionTXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. LEVEL OF EVIDENCE: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.

Indexed as

Acetabulum fractureAntifibrinolysisOrthopaedic traumaPelvic fractureTranexamic acid

Identifiers

PMID34924726
PMCPMC8648565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.