Evidence map›Paper›PMID 34924586›Full record

ArticleApplied biochemistry and microbiology2021

Loop-Mediated Isothermal Amplification as a Promising Method for Mass COVID-19 Diagnostics.

J A Makarova, K A Fomicheva, A I Osipyants, M Yu Shkurnikov, A A Pokryshchenko, E A Tonevitsky, V I Vechorko

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied biochemistry and microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

J A MakarovaFaculty of Biology and Biotechnology, Higher School of Economics National Research University, 101000 Moscow, Russia.
K A FomichevaHertsen Moscow Oncology Research Institute, National Center of Medical Radiological Research, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
A I OsipyantsHertsen Moscow Oncology Research Institute, National Center of Medical Radiological Research, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
M Yu ShkurnikovHertsen Moscow Oncology Research Institute, National Center of Medical Radiological Research, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
A A PokryshchenkoFaculty of Biology and Biotechnology, Higher School of Economics National Research University, 101000 Moscow, Russia.
E A TonevitskyDevelopment Fund, Mendeleev Valley, Innovative Scientific and Technological Center, 125480 Moscow, Russia.
V I VechorkoFilatov City Clinical Hospital no. 15, Department of Health of Moscow, 111539 Moscow, Russia.
National Research University Higher School of Economics · RUP.A. Hertzen Moscow Oncology Research Institute · RUCity Clinical Hospital No15 named. O. M. Filatova · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-time reverse-transcription polymerase chain reaction (RT-PCR) is currently the most popular method for early COVID-19 diagnostics. However, loop-mediated isothermal amplification (LAMP) is superior to real-time RT-PCR in rapidity and simplicity, since it does not require expensive laboratory equipment and trained personnel. LAMP-based diagnostic kits for COVID-19 testing already exist, but corresponding tests are not yet widely available. The method has great potential for mass application. Here, we discuss the technical and methodological aspects of its widespread adoption.

Indexed as

coronavirusCOVID-19diagnosticsLAMPloop-mediated isothermal amplificationSARS-CoV-2

Identifiers

PMID34924586
PMCPMC8670616
OpenAlexW4200326086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.