Evidence map›Paper›PMID 34924289›Full record

ReviewTrends in plant science2022

TALE-induced cell death executors: an origin outside immunity?

Moritz K Nowack, Danalyn R Holmes, Thomas Lahaye

Open access · hybridAbstract readReview
In one paragraph

Review in Trends in plant science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Extracellular niche establishment by plant pathogens.Nature reviews. Microbiology · 2024
    Review
  8. Article
  9. Article
  10. Disease resistance features of the executorFrontiers in plant science · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Ectopic Expression of Executor GeneInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Moritz K NowackDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; VIB Center of Plant Systems Biology, 9052 Ghent, Belgium. Electronic address: Moritz.Nowack@psb.vib-ugent.be.
Danalyn R HolmesUniversity of Tübingen, ZMBP - General Genetics, Auf der Morgenstelle 32, 72076 Tuebingen, Germany.
Thomas LahayeUniversity of Tübingen, ZMBP - General Genetics, Auf der Morgenstelle 32, 72076 Tuebingen, Germany. Electronic address: Thomas.lahaye@zmbp.uni-tuebingen.de.
University of Tübingen · DEGhent University · BE

Funding

European Research Council 864952
6 · The paper itself

Abstract

Phytopathogenic bacteria inject effector proteins into plant host cells to promote disease. Plant resistance (R) genes encoding nucleotide-binding leucine-rich repeat (NLR) proteins mediate the recognition of functionally and structurally diverse microbial effectors, including transcription-activator like effectors (TALEs) from the bacterial genus Xanthomonas. TALEs bind to plant promoters and transcriptionally activate either disease-promoting host susceptibility (S) genes or cell death-inducing executor-type R genes. It is perplexing that plants contain TALE-perceiving executor-type R genes in addition to NLRs that also mediate the recognition of TALE-containing xanthomonads. We present recent findings on the evolvability of TALEs, which suggest that the native function of executors is not in plant immunity, but possibly in the regulation of developmentally controlled programmed cell death (PCD) processes.

Indexed as

Gene Expression Regulation, PlantXanthomonasBacterial ProteinsCell DeathPlant DiseasesPlantsTranscription Activator-Like EffectorsBacterial ProteinsTranscription Activator-Like Effectorsevolutionexecutornucleotide-binding leucine-rich repeat (NLR) proteinprogrammed cell death (PCD)transcription activator-like effector (TALE)Xanthomonas

Identifiers

PMID34924289
PMCPMC7612725
OpenAlexW4200283708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.