ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022
Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Selective decrease of donor-reactive TScience translational medicine · 2022Trial
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Telomere biology disorders in lung transplantation: Clinical challenges and management strategies.JHLT open · 2025Review
- The search for peripheral tolerance in lung transplantation.Current opinion in pulmonary medicine · 2025Review
- Viewpoint: Pre- and post-lung transplant considerations for patients with ultra-short telomere length.The European respiratory journal · 2025Article
- An epigenetic human cytomegalovirus infection score predicts viremia risk in seropositive lung transplant recipients.Epigenetics · 2024Article
- Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Donor age over 55 is associated with worse outcome in lung transplant recipients with idiopathic pulmonary fibrosis.BMC pulmonary medicine · 2024Article
- Article
- Novel kinase 1 regulates CD8+T cells as a potential therapeutic mechanism for idiopathic pulmonary fibrosis.International journal of medical sciences · 2024Article
- Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients.Frontiers in transplantation · 2024Review
- Innate and adaptive effector immune drivers of cytomegalovirus disease in lung transplantation: a double-edged sword.Frontiers in transplantation · 2024Review
- Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease.The European respiratory journal · 2023Article
- NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.JCI insight · 2022Article
- Associations between shortened telomeres and rheumatoid arthritis-associated interstitial lung disease among U.S. Veterans.Respiratory medicine · 2022Article
- The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.Current transplantation reports · 2022Article
- Editorial: Immune Aging: Implications for Transplantation.Frontiers in immunology · 2022Article
- Lymphocytic Airway Inflammation in Lung Allografts.Frontiers in immunology · 2022Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTelomere dysfunction is associated with idiopathic pulmonary fibrosis (IPF) and worse outcomes following lung transplantation. Telomere dysfunction may impair immunity by upregulating p53 and arresting proliferation, but its influence on allograft-specific immune responses is unknown. We hypothesized that subjects undergoing lung transplantation for IPF would have impaired T cell proliferation to donor antigens.
methodsWe analyzed peripheral blood mononuclear cells (PBMC) from 14 IPF lung transplant recipients and 12 age-matched non-IPF subjects, before and 2 years after transplantation, as well as PBMC from 9 non-transplant controls. We quantified T cell proliferation and cytokine secretion to donor antigens. Associations between PBMC telomere length, measured by quantitative PCR, and T cell proliferation to alloantigens were evaluated with generalized estimating equation models.
resultsIPF subjects demonstrated impaired CD8+ T cell proliferation to donor antigens pre-transplant (p < 0.05). IL-2, IL-7, and IL-15 cytokine stimulation restored T cell proliferation, while p53 upregulation blocked proliferation. IPF subjects had shorter PBMC telomere lengths than non-IPF subjects (p < 0.001), and short PBMC telomere length was associated with impaired CD8+ T cell proliferation to alloantigens (p = 0.002).
conclusionsIPF as an indication for lung transplant is associated with short PBMC telomere length and impaired T cell responses to donor antigens. However, the rescue of proliferation following cytokine exposure suggests that alloimmune anergy could be overcome. Telomere length may inform immunosuppression strategies for IPF recipients.
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