ArticleVeterinary research2021
Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain.
Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- Bis-glycinate bound zinc supplementation in sows modulates sows and piglets gut microbiota and reduces piglet diarrhea incidence.Scientific reports · 2026Article
- Disease-associated Streptococcus suis (DASS) in lactation: detection patterns and implications for control.Porcine health management · 2025Article
- A new lymph node infection model for Streptococcus suis serotype 2 in pigs.Veterinary research · 2025Article
- Review
- The kinetics of maternal and self-developed Streptococcus suis-specific antibodies.Porcine health management · 2025Article
- The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes.Frontiers in immunology · 2025Article
- Article
- Emerging Approaches for Mitigating Biofilm-Formation-Associated Infections in Farm, Wild, and Companion Animals.Pathogens (Basel, Switzerland) · 2024Review
- Antiviral Drug Candidate Repositioning forBiomedicines · 2024Article
- Streptococcus suis serotype 9 in Italy: genomic insights into high-risk clones with emerging resistance to penicillin.The Journal of antimicrobial chemotherapy · 2024Article
- Transcriptional Host Responses to Infection withPathogens (Basel, Switzerland) · 2023Article
- A critical review on experimental Streptococcus suis infection in pigs with a focus on clinical monitoring and refinement strategies.BMC veterinary research · 2023Review
- Role of Metabolic Adaptation ofPathogens (Basel, Switzerland) · 2023Review
- Human HLA prolongs the host inflammatory response inFrontiers in cellular and infection microbiology · 2023Article
- Cell membrane-coated nanoparticles: An emerging antibacterial platform for pathogens of food animals.Frontiers in veterinary science · 2023Review
- ARadiology case reports · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Streptococcus suis is a zoonotic pathogen of swine involved in arthritis, polyserositis, and meningitis. Colonization of piglets by S. suis is very common and occurs early in life. The clinical outcome of infection is influenced by the virulence of the S. suis strains and the immunity of the animals. Here, the role of innate immunity was studied in cesarean-derived colostrum-deprived piglets inoculated intranasally with either virulent S. suis strain 10 (S10) or non-virulent S. suis strain T15. Colonization of the inoculated piglets was confirmed at the end of the study by PCR and immunohistochemistry. Fever (≥40.5 °C) was more prevalent in piglets inoculated with S10 compared to T15 at 4 h after inoculation. During the 3 days of monitoring, no other major clinical signs were detected. Accordingly, only small changes in transcription of genes associated with the antibacterial innate immune response were observed at systemic sites, with S10 inducing an earlier response than T15 in blood. Local inflammatory response to the inoculation, evaluated by transcriptional analysis of selected genes in nasal swabs, was more sustained in piglets inoculated with the virulent S10, as demonstrated by transcription of inflammation-related genes, such as IL1B, IL1A, and IRF7. In contrast, most of the gene expression changes in trachea, lungs, and associated lymph nodes were observed in response to the non-virulent T15 strain. Thus, S. suis colonization in the absence of systemic infection induces an innate immune response in piglets that appears to be related to the virulence potential of the colonizing strain.
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Registered trials
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