ArticleJournal of medical case reports2021
Co-occurrence of sickle cell disease and oculocutaneous albinism in a Congolese patient: a case report.
Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Albinism and Blood Cell Profile: The Peculiar Case of Asinara Donkeys.Animals : an open access journal from MDPI · 2024Article
- Genetic analysis of albinism caused by compound heterozygous mutations of the OCA2 gene in a Chinese family.Hereditas · 2024Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
backgroundSickle cell disease and oculocutaneous albinism are rare autosomal recessive disorders both related to mutations on chromosome 11. The diagnosis of patients suffering from both pathologies is necessary to enable dedicated monitoring of any complications at the ophthalmic and skin level. However, few cases are described in the literature. CASE PRESENTATION: A 14-month-old Congolese male child affected by oculocutaneous albinism, presented with pallor and jaundice. Blood indices revealed severe hemolytic anemia, which led to the diagnosis of sickle cell disease. The patient received a blood transfusion and close follow-up.
conclusionsThe co-inheritance of sickle cell disease and oculocutaneous albinism is a reality in the Democratic Republic of Congo, although it is rarely described. Given the current state of our knowledge, specific surveillance, specifically regarding cutaneous and ophthalmological complications, should be offered in this particular population. To enable this dedicated follow-up, sensitization to screening for sickle cell anemia in albino individuals should be carried out.
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