Evidence map›Paper›PMID 34923919›Full record

ArticlemAbs

Development of a nonhuman primate challenge model to evaluate CD8

Richard Graveline, Morad Haida, Carolyne Dumont, Dominic Poulin, Florence Poitout-Belissent, Rana Samadfam, Sven Kronenberg, Franziska Regenass-Lechner, Rodney Prell, Marie-Soleil Piche

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Richard GravelineImmunology, Charles River Laboratories, Senneville, Canada.
Morad HaidaImmunology, Charles River Laboratories, Senneville, Canada.
Carolyne DumontImmunology, Charles River Laboratories, Senneville, Canada.
Dominic PoulinImmunology, Charles River Laboratories, Senneville, Canada.
Florence Poitout-BelissentImmunology, Charles River Laboratories, Senneville, Canada.
Rana SamadfamImmunology, Charles River Laboratories, Senneville, Canada.
Sven KronenbergRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
Franziska Regenass-LechnerRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
Rodney PrellSafety Assessment, Development Sciences, Genentech, South San Francisco, CA, USA.
Marie-Soleil PicheImmunology, Charles River Laboratories, Senneville, Canada.
Roche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting immune checkpoint receptors expressed in the T cell synapse induces active and long-lasting antitumor immunity in preclinical tumor models and oncology patients. However, traditional nonhuman primate (NHP) studies in healthy animals have thus far demonstrated little to no pharmacological activity or toxicity for checkpoint inhibitors (CPIs), likely due to a quiescent immune system. We developed a NHP vaccine challenge model in Mauritius cynomolgus monkey (MCMs) that elicits a strong CD8

Indexed as

AdenoviridaeSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeAnimalsCD8-Positive T-LymphocytesDrug EvaluationMacaca fascicularisMaleSimian Immunodeficiency VirusSAIDS VaccinesadenovirusCD8 t cell functioncheckpoint inhibitorsnonhuman primateSIV antigen challenge

Identifiers

PMID34923919
PMCPMC8726661
OpenAlexW4200518905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.