Evidence map›Paper›PMID 34923900›Full record

ArticleGut microbes

The ancestral stringent response potentiator, DksA has been adapted throughout

Helit Cohen, Boaz Adani, Emiliano Cohen, Bar Piscon, Shalhevet Azriel, Prerak Desai, Heike Bähre, Michael McClelland, Galia Rahav, Ohad Gal-Mor

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Assessing transcriptomic responses ofMicrobiology spectrum · 2026
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  7. The Effect of Erythromycin in Macrolide-resistantCurrent pharmaceutical biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Helit CohenSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Boaz AdaniSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Emiliano CohenSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Bar PisconSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Shalhevet AzrielSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Prerak DesaiJanssen Research & Development, LLC, Raritan, New Jersey, USA.
Heike BähreHannover Medical School, Research Core Unit Metabolomics, Hannover, Germany.
Michael McClellandDepartment of Microbiology and Molecular Genetics, University of California, Irvine, California, USA.
Galia RahavSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Ohad Gal-MorSheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
Sheba Medical Center · ILInfectious Diseases and the Research Institute · USJanssen (United States) · USMedizinische Hochschule Hannover · DEOffice of Infectious Diseases · USTel Aviv University · ILUniversity of California System · US

Funding

Salmonella evasion of NADPH oxidase-dependent killingR01AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2003 to 2018
$5.2M
Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
NIAID NIH HHS R01 AI054959NIAID NIH HHS R01 AI136520
6 · The paper itself

Abstract

DksA is a conserved RNA polymerase-binding protein known to play a key role in the stringent response of proteobacteria species, including many gastrointestinal pathogens. Here, we used RNA-sequencing of

Indexed as

Evolution, MolecularBacterial ProteinsCitric Acid CycleEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGene Transfer, HorizontalGlycolysisHumansPyrimidinesRegulonSalmonellaSalmonella InfectionsSalmonella typhimuriumVirulenceVirulence FactorsBacterial ProteinsdksA protein, E coliDksA protein, Salmonella typhimuriumEscherichia coli ProteinspyrimidinePyrimidinesVirulence FactorsDksAenteric pathogensHGTpathogenicityregulationRNA-SeqSalmonellaSPIsvirulence

Identifiers

PMID34923900
PMCPMC8726615
OpenAlexW4200249676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.