ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2022
High-frequency ultrasound for differentiation between high-risk basal cell carcinoma and cutaneous squamous cell carcinoma.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- From Ultrasound to Histopathology: Agreement Analysis and Depth Correction Model for Basal Cell Carcinoma Using a Portable 20 MHz High-Frequency Ultrasound Device.Diagnostics (Basel, Switzerland) · 2026Article
- Utility of High-Frequency Ultrasound in Preoperative Evaluation of the Thickness of Cutaneous Melanoma.Diagnostics (Basel, Switzerland) · 2026Article
- Giant vulvar verruciform xanthoma in a child: a rare case report and literature review.Frontiers in medicine · 2026Article
- Enhancing Diagnosis in Squamous Cell Carcinoma: Non-Invasive Imaging and Multimodal Approach.Diagnostics (Basel, Switzerland) · 2025Article
- Advances in Skin Ultrasonography for Malignant and Benign Tumors of the Head and Neck: Current Insights and Future Directions.Journal of clinical medicine · 2025Review
- Noninvasive Technologies for the Diagnosis of Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.JID innovations : skin science from molecules to population health · 2024Review
- Differential Expression Analysis of Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma Proteomic Profiles Sampled with Electroporation-Based Biopsy.JID innovations : skin science from molecules to population health · 2024Article
- Ultrasound in Skin Cancer: Why, How, and When to Use It?Cancers · 2024Review
- Basal cell carcinoma and squamous cell carcinoma: Comparison of high-frequency ultrasound and pathology.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Role of high-frequency ultrasound in differentiating benign and malignant skin lesions: potential and limitations.Ultrasonography (Seoul, Korea) · 2024Article
- An overview of cutaneous squamous cell carcinoma imaging diagnosis methods.Frontiers in medicine · 2024Review
- Electroporation-Based Biopsy Treatment Planning with Numerical Models and Tissue Phantoms.Annals of biomedical engineering · 2024Article
- High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas.Diagnostics (Basel, Switzerland) · 2023Article
- Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts.International journal of molecular sciences · 2023Review
- High-frequency ultrasound for differentiation between high-risk basal cell carcinoma and cutaneous squamous cell carcinoma.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Morphological aspects of basal cell carcinoma vascularization.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe similar visual appearance of high-risk basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) may cause confusion for diagnosis. High-frequency ultrasound (HFUS) may provide additional intralesional information and thus help to distinguish them.
methodIn this retrospective study, we analyzed the clinical characteristics, HFUS grayscale, and color Doppler flow imaging (CDFI) features of pathologically confirmed high-risk BCC and cSCC lesions (n = 65 vs n = 68). Subsequently, discrimination models based on the significant HFUS features were established.
resultsBetween high-risk BCC and cSCC lesions, the HFUS grayscale features of the lesion size (10.0 mm vs 17.4 mm), thickness (3.1 mm vs 5.9 mm), internal hyperechoic spots (80.0% vs 23.5%), and posterior acoustic shadowing (16.9% vs 66.2%) were statistically different (all p < 0.001). As for the CDFI features, high-risk BCC lesions mainly appeared as pattern II (47.7%), while cSCC lesions mainly appeared as pattern III (66.2%). Based on the above five features, an optimal discrimination model was established with a sensitivity of 91.2%, a specificity of 87.7%, and an accuracy of 89.5%.
conclusionHFUS features, including size, thickness, internal hyperechoic spots, posterior acoustic shadowing, and Doppler vascularity pattern, are useful for differential diagnosis between high-risk BCC and cSCC.
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