SynthesisInternational journal of implant dentistry2021
Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review.
Synthesis in International journal of implant dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- The Clinical Effectiveness of Platelet-Rich Fibrin in Post-Extraction Healing: A Systematic Review of Randomized Controlled Trials.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing process and bone repair in maxillary sinus lift surgeries: a systematic review.Cell and tissue banking · 2025Pooled it
- Hyaluronic acid as a promoter of the healing of post-extraction socket treated with the socket preservation technique: a systematic review.Frontiers in oral health · 2025Pooled it
- Platelet-rich fibrin as a hemostatic agent in dental extractions in patients taking anticoagulants or antiplatelet medication: a systematic review.Clinical oral investigations · 2024Pooled it
- Wound Healing Patterns of PRF and PRGF Versus a Collagen-Based Substitute and Spontaneous Healing-A Randomised Controlled Clinical Trial Assessing Wound Closure of an Experimental, Standardised Palatal Defect.Journal of clinical periodontology · 2026Trial
- Clinical and radiographic efficacy of photobiomodulation, platelet-rich fibrin, and their combination for socket preservation: a randomized clinical trial.BMC oral health · 2026Trial
- Platelet-Rich Fibrin in Surgical Wound Healing of Medication-Related Osteonecrosis of the Jaw: A Pilot Clinical Study.International journal of molecular sciences · 2026Trial
- Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Effect of platelet-rich fibrin on microperfusion during early socket healing: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Socket Preservation Using Platelet-Rich Fibrin and Free Gingival Grafts.International dental journal · 2025Trial
- Comparison of histologic and radiographic changes of sockets grafted with LPRF and sockets without intervention after tooth extraction.Oral and maxillofacial surgery · 2024Trial
- Platelet-rich fibrin vs. buccal advancement flap for closure of oroantral communications: a prospective clinical study.Clinical oral investigations · 2023Trial
- Effectiveness of platelet-rich fibrin concentrates in alveolar ridge preservation after tooth extraction: A systematic review of randomized clinical trials with tomographic evaluation.Clinics (Sao Paulo, Brazil) · 2026Review
- Membrane Fixation and Graft Persistence in Pre-Extraction Buccal Overbuilding: A Split-Mouth Histological Study in Dogs.Dentistry journal · 2026Article
- Research interests and trends in alveolar ridge augmentation and visualization of articles from 1990 to 2024: a bibliometric analysis.The Saudi dental journal · 2026Article
- Effectiveness of Autologous Plasma Rich in Growth Factors on Healing of Extraction Socket-A Systematic Review.Journal of clinical medicine · 2026Review
- Comparative Efficacy of Platelet-Rich Fibrin, Freeze-Dried Bone Allograft, or Spontaneous Healing for Alveolar Ridge Preservation: Systematic Review and Meta-Analysis.Bioengineering (Basel, Switzerland) · 2025Review
- Surgical Management of an Impacted Mandibular Second Premolar in Close Proximity to the Mental Foramen: A Case Report.Reports (MDPI) · 2025Article
- Diagnostic and Clinical Outcomes of Three Regenerative Strategies for Alveolar Bone Defects: A Comparative Study Using CBCT and ISQ.Diagnostics (Basel, Switzerland) · 2025Article
- Patient reported pain following tooth extraction with different autologous platelet concentrates. Systematic review.BDJ open · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment?
methodsAfter an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included.
results66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1-3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8-15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing.
conclusionsBased on the analyzed studies, PRF is most effective in the early healing period of 2-3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.