Trial reportEuropean journal of drug metabolism and pharmacokinetics2022
A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette.
Trial report in European journal of drug metabolism and pharmacokinetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Evaluation of high-nicotine oral products shows potential to reduce tobacco-related harm by offering satisfying alternatives.Scientific reports · 2025Trial
- Characterization of the nicotine uptake and safety of Nordic spirit tobacco-free oral nicotine pouches: A randomized cross-over study.Psychopharmacology · 2025Trial
- Evaluating the Role of Nicotine Stereoisomer on Nicotine Pouch Abuse Liability: A Randomized Crossover Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Using Pod Based e-Cigarettes and Nicotine Pouches to Reduce Harm for Adults With Low Socioeconomic Status Who Smoke: A Pilot Randomized Controlled Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- Evaluating the effects of nicotine concentration on the appeal and nicotine delivery of oral nicotine pouches among rural and Appalachian adults who smoke cigarettes: A randomized cross-over study.Addiction (Abingdon, England) · 2024Trial
- A randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products.Scientific reports · 2022Trial
- Development of a model to predict nicotine pharmacokinetics from oral nicotine pouches.Scientific reports · 2026Article
- Nicotine Pouch Use and Intentions to Quit Cigarette Smoking Among U.S. Adults.Journal of prevention (2022) · 2026Article
- Effects of nicotine concentration and pH on nicotine pouch appeal and sensory experience: A randomized experimental study.Addiction (Abingdon, England) · 2026Article
- [Smoking and nicotine use, heated tobacco products, psychological and socioeconomic aspects of dependence, alcohol, infections, vaccination and diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Nicotine pouches: an aid in smoking cessation, or a new public health hazard?Internal and emergency medicine · 2026Review
- Oral nicotine pouches have arrived at U.S. college campuses.Journal of American college health : J of ACH · 2026Article
- Association of tobacco and other substance use with nicotine pouch awareness and use in US adolescents.Drug and alcohol dependence · 2026Article
- Biomarkers of Exposure to Tobacco-Related Toxicants among Adult Nicotine Pouch Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Nicotine delivery from and user reactions to nicotine pouches compared to cigarettes.Psychopharmacology · 2025Article
- Nicotine pouch pharmacokinetics compared to smoked tobacco: A systematic review and meta-analysis.Drug and alcohol dependence reports · 2025Review
- Use of nicotine pouches among adults who currently or formerly smoked cigarettes and/or vaped nicotine: findings from the 2022 and 2024 US ITC smoking and vaping surveys.Tobacco control · 2025Article
- Physiological and subjective effects of an oral nicotine pouch in people who use smokeless tobacco.Experimental and clinical psychopharmacology · 2025Article
- Prevalence, safety, and role of nicotine pouches in smoking cessation among smokers and the public in Saudi Arabia.Scientific reports · 2025Article
- Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults.Tobacco control · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesNicotine pouches (NPs) are a relatively new type of oral smokeless tobacco-free nicotine product. Currently, few data are available on the nicotine pharmacokinetics or subjective effects of NP use. The objective of this study was to determine and compare the pharmacokinetics of nicotine absorption into the blood from different NP variants and a combustible cigarette.
methodsIn a randomised, controlled, crossover clinical study, nicotine pharmacokinetics and subjective effects were compared among commercially available NPs (five different brands; 6-10 mg nicotine/pouch) and a combustible cigarette. During an 8-day confinement period, 35 healthy adult participants who were current dual users of snus and combustible cigarettes used one study product each day for a defined period following overnight nicotine abstinence.
resultsNicotine maximum plasma concentration (C
conclusionsThis study provides important insight into nicotine pharmacokinetics and subjective effects during NP use, and demonstrates that NPs can provide nicotine in amounts sufficient to replicate cigarette smokers' nicotine uptake following a switch from conventional cigarettes to these potentially less harmful NP products. Further studies are required to ascertain how physical characteristics of NPs other than nicotine content may affect nicotine delivery, pharmacokinetics and subjective responses. ISRCTN CLINICAL TRIAL REGISTRY: ISRCTN17828518.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.