ArticleAnnals of epidemiology2022
High-sensitivity C-reactive protein and all-cause mortality in four diverse populations: The CRONICAS Cohort Study.
Article in Annals of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Elevated alpha-1 antitrypsin and C-reactive protein: association on all-cause and cause-specific mortality in older adults.GeroScience · 2026Trial
- Moderate intensity walking exercises reduce the body mass index and vascular inflammatory factors in postmenopausal women with obesity: a randomized controlled trial.Scientific reports · 2023Trial
- A novel DNA methylation-based surrogate biomarker for chronic systemic inflammation (Inflammation Latent Variable Methylation Surrogate, InfLaMeS).The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The trajectory of frailty index and its association with rapid decline in kidney function and the incidence of chronic kidney disease: evidence from the China health and retirement longitudinal study.Aging clinical and experimental research · 2025Article
- A Phenome-Wide association study (PheWAS) of genetic risk for C-reactive protein in children of European Ancestry: Results from the ABCD study.Brain, behavior, and immunity · 2025Article
- Relating Biopsychosocial Meanings to Semi-Quantitative CRP Readings Among Primary Healthcare Users: Trends from a Cross-Sectional Study Analysis.Journal of clinical medicine · 2025Article
- Role of C-Reactive Protein as a Predictor of Early Revascularization and Mortality in Advanced Peripheral Arterial Disease.Journal of clinical medicine · 2025Article
- Dynamic changes in hs-CRP and risk of all-cause mortality among middle-aged and elderly adults: findings from a nationwide prospective cohort and mendelian randomization.Aging clinical and experimental research · 2024Article
- A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study.medRxiv : the preprint server for health sciences · 2024Article
- Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.BMC geriatrics · 2024Article
- Synergistic effect of lipoprotein(a) and high-sensitivity C-reactive protein on the risk of all-cause and cardiovascular death in patients with acute myocardial infarction: a large prospective cohort study.Frontiers in endocrinology · 2024Article
- Thymic function and survival at advance ages in nursing home residents from Southern Italy.Immunity & ageing : I & A · 2023Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeTo assess the association between all-cause mortality and hs-CRP, based mainly on the cumulative burden approach.
methodsCohort study with adults ≥35 years from general population, using hs-CRP at two timepoints: at baseline and 30 months later to establish different exposures: change over time, cumulative, and weighted cumulative hs-CRP. The outcome was all-cause mortality assessed 7 years later. Cox models were generated to quantify the association.
resultsData from 3,119 participants (mean age 55.6 years, and 51.2% females), were analyzed. During follow-up, 164 (5.6%) deaths occurred over 20,314.5 person-years, indicating an overall mortality rate of 8.1 per 1,000 person-years. In multivariable model, hs-CRP at baseline was associated with high risk of mortality (HR = 1.77; 95%CI: 1.28-2.46). Similarly, hs-CRP change over time (HR = 2.50; 95%CI: 1.46-4.29), as well as cumulative and weighted cumulative hs-CRP (HR = 2.05; 95%CI: 1.31-3.20) were associated with greater risk of all-cause mortality. The weighted cumulative hs-CRP had the best goodness-of-fit for mortality prediction.
conclusionsIn this cohort across diverse geographical low-resource settings, high levels of hs-CRP were strongly associated with all-cause mortality. Two measurements of hs-CRP are better than one to predict mortality, and the weighted cumulative approach had the best prognostic fit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.