Evidence map›Paper›PMID 34922776›Full record

ArticleAnnals of emergency medicine2022

Sustained Implementation of a Multicomponent Strategy to Increase Emergency Department-Initiated Interventions for Opioid Use Disorder.

Margaret Lowenstein, Jeanmarie Perrone, Ruiying A Xiong, Christopher K Snider, Nicole O'Donnell, Davis Hermann, Roy Rosin, Julie Dees, Rachel McFadden, Utsha Khatri and 3 more

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Annals of emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. The role of information systems in emergency department decision-making-a literature review.Journal of the American Medical Informatics Association : JAMIA · 2024
    Pooled it
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  5. Navigating Substance Use Care in the Emergency Department: A Scoping Review.Journal of the American College of Emergency Physicians open · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Margaret LowensteinDivision of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA. Electronic address: margaw@pennmedicine.upenn.edu.
Jeanmarie PerroneDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA.
Ruiying A XiongDivision of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Christopher K SniderCenter for Health Care Innovation, Penn Medicine, Philadelphia, PA.
Nicole O'DonnellDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Davis HermannCenter for Health Care Innovation, Penn Medicine, Philadelphia, PA.
Roy RosinCenter for Health Care Innovation, Penn Medicine, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
Julie DeesFamily Service Association of Bucks County, Langhorne, PA.
Rachel McFaddenDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Utsha KhatriDepartment of Emergency Medicine, Mount Sinai Icahn School of Medicine, New York, NY.
Zachary F MeiselDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
Nandita MitraDepartment of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
M Kit DelgadoDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
University of Pennsylvania · USPenn Center for AIDS Research · USBucks County Community College · USIcahn School of Medicine at Mount Sinai · US

Funding

CE19-001, The Penn Injury Science CenterR49CE003083 · CE · UNIVERSITY OF PENNSYLVANIA · PI MEISEL, ZACHARY FRANKLIN · 2018 to 2023
$4.4M
Reducing Risky Teen Cellphone Use While Driving Using Behavioral Economics, Technology, and EpidemiologyK23HD090272 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI DELGADO, MUCIO · 2017 to 2020
$675k
ACL HHS R49CE003083NCIPC CDC HHS R49 CE003083NICHD NIH HHS K23 HD090272
6 · The paper itself

Abstract

STUDY

objectiveThere is strong evidence supporting emergency department (ED)-initiated buprenorphine for opioid use disorder, but less is known about how to implement this practice. Our aim was to describe implementation, maintenance, and provider adoption of a multicomponent strategy for opioid use disorder treatment in 3 urban, academic EDs.

methodsWe conducted a retrospective analysis of electronic health record data for adult patients with opioid use disorder-related visits before (March 2017 to November 2018) and after (December 2018 to July 2020) implementation. We describe patient characteristics, clinical treatment, and process measures over time and conducted an interrupted time series analysis using a patient-level multivariable logistic regression model to assess the association of the interventions with buprenorphine use and other outcomes. Finally, we report provider-level variation in prescribing after implementation.

resultsThere were 2,665 opioid use disorder-related visits during the study period: 28% for overdose, 8% for withdrawal, and 64% for other conditions. Thirteen percent of patients received medications for opioid use disorder during or after their ED visit overall. Following intervention implementation, there were sustained increases in treatment and process measures, with a net increase in total buprenorphine of 20% in the postperiod (95% confidence interval 16% to 23%). In the adjusted patient-level model, there was an immediate increase in the probability of buprenorphine treatment of 24.5% (95% confidence interval 12.1% to 37.0%) with intervention implementation. Seventy percent of providers wrote at least 1 buprenorphine prescription, but provider-level buprenorphine prescribing ranged from 0% to 61% of opioid use disorder-related encounters.

conclusionA combination of strategies to increase ED-initiated opioid use disorder treatment was associated with sustained increases in treatment and process measures. However, adoption varied widely among providers, suggesting that additional strategies are needed for broader uptake.

Indexed as

AdultBuprenorphineEmergency Service, HospitalFemaleHumansMaleMiddle AgedNarcotic AntagonistsOpioid-Related DisordersPractice Patterns, Physicians'Quality ImprovementRetrospective StudiesBuprenorphineNarcotic Antagonists

Identifiers

PMID34922776
PMCPMC8860858
OpenAlexW4200343406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.