Evidence map›Paper›PMID 34922769›Full record

Observational studyGynecologic oncology2022

COVID-19 outcomes of patients with gynecologic cancer in New York City: An updated analysis from the initial surge of the pandemic.

Olivia D Lara, Maria Smith, Yuyan Wang, Roisin E O'Cearbhaill, Stephanie V Blank, Valentin Kolev, Caitlin Carr, Anne Knisely, Jennifer McEachron, Lisa Gabor and 8 more

Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Gynecologic oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Olivia D LaraDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, United States of America.
Maria SmithDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, United States of America.
Yuyan WangDepartment of Population Health, NYU Langone Health, New York, NY, United States of America.
Roisin E O'CearbhaillDepartment of Medical Oncology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, United States of America.
Stephanie V BlankDepartment of Obstetrics, Gynecologic and Reproductive Science, Division of Gynecologic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Valentin KolevDepartment of Obstetrics, Gynecologic and Reproductive Science, Division of Gynecologic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Caitlin CarrDepartment of Obstetrics, Gynecologic and Reproductive Science, Division of Gynecologic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Anne KniselyDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America.
Jennifer McEachronDepartment of Obstetrics and Gynecology, State University of New York Downstate Medical Center, Brooklyn, NY, United States of America.
Lisa GaborDepartment of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, United States of America.
Eloise Chapman-DavisDepartment of Obstetrics & Gynecology, Cornell University, New York, NY, United States of America.
Seth CohenDepartment of Medical Oncology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, United States of America.
Julia FehnigerDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, United States of America.
Yi-Chun LeeDepartment of Obstetrics and Gynecology, State University of New York Downstate Medical Center, Brooklyn, NY, United States of America.
Sara IsaniDepartment of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, United States of America.
Mengling LiuDepartment of Population Health, NYU Langone Health, New York, NY, United States of America; Department of Environmental Medicine, NYU Langone Health, New York, NY, United States of America.
Jason D WrightDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America.
Bhavana PothuriDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, United States of America. Electronic address: bhavana.pothuri@nyulangone.org.
Icahn School of Medicine at Mount Sinai · USColumbia University · USCornell University · USNYU Langone Health · USState University of New York · USAlbert Einstein College of Medicine · USMemorial Sloan Kettering Cancer Center · USMontefiore Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundDespite significant increase in COVID-19 publications, characterization of COVID-19 infection in patients with gynecologic cancer remains limited. Here we present an update of COVID-19 outcomes among people with gynecologic cancer in New York City (NYC) during the initial surge of severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]).

methodsData were abstracted from gynecologic oncology patients with COVID-19 infection among 8 NYC area hospital systems between March and June 2020. Multivariable logistic regression was utilized to estimate associations between factors and COVID-19 related hospitalization and mortality.

resultsOf 193 patients with gynecologic cancer and COVID-19, the median age at diagnosis was 65.0 years (interquartile range (IQR), 53.0-73.0 years). One hundred six of the 193 patients (54.9%) required hospitalization; among the hospitalized patients, 13 (12.3%) required invasive mechanical ventilation, 39 (36.8%) required ICU admission. Half of the cohort (49.2%) had not received anti-cancer treatment prior to COVID-19 diagnosis. No patients requiring mechanical ventilation survived. Thirty-four of 193 (17.6%) patients died of COVID-19 complications. In multivariable analysis, hospitalization was associated with an age ≥ 65 years (odds ratio [OR] 2.12, 95% confidence interval [CI] 1.11, 4.07), Black race (OR 2.53, CI 1.24, 5.32), performance status ≥2 (OR 3.67, CI 1.25, 13.55) and ≥ 3 comorbidities (OR 2.00, CI 1.05, 3.84). Only former or current history of smoking (OR 2.75, CI 1.21, 6.22) was associated with death due to COVID-19 in multivariable analysis. Administration of cytotoxic chemotherapy within 90 days of COVID-19 diagnosis was not predictive of COVID-19 hospitalization (OR 0.83, CI 0.41, 1.68) or mortality (OR 1.56, CI 0.67, 3.53).

conclusionsThe case fatality rate among patients with gynecologic malignancy with COVID-19 infection was 17.6%. Cancer-directed therapy was not associated with an increased risk of mortality related to COVID-19 infection.

Indexed as

AdultAgedAged, 80 and overCarcinomaCOVID-19FemaleGenital Neoplasms, FemaleHospitalizationHumansLogistic ModelsMiddle AgedNew York CityPatient AcuityRetrospective StudiesRisk FactorsTreatment OutcomeCoronavirus disease 2019 (COVID-19)Gynecologic cancerOutcomesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID34922769
PMCPMC8648583
OpenAlexW4200258236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.