Evidence map›Paper›PMID 34922622›Full record

ArticleParasites & vectors2021

Insecticide susceptibility status and knockdown resistance (kdr) mutation in Aedes albopictus in China.

Yong Wei, Xueli Zheng, Song He, Xuli Xin, Jiachun Zhang, Ke Hu, Guofa Zhou, Daibin Zhong

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Detection of insecticide resistance and knockdown resistance (Frontiers in cellular and infection microbiology · 2026
    Article
  4. Mechanisms and genetic mutations of pyrethroid resistance inFrontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Evolution of knockdown resistance (Frontiers in cellular and infection microbiology · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yong WeiClinical Laboratory, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China. smuweiyong@163.com.
Xueli ZhengDepartment of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou, China. zhengxueli2001@126.com.
Song HeClinical Laboratory, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China. maxhe@163.com.
Xuli XinClinical Laboratory, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China.
Jiachun ZhangClinical Laboratory, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China.
Ke HuDepartment of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou, China.
Guofa ZhouProgram in Public Health, College of Health Sciences, University of California, Irvine, CA, USA.
Daibin ZhongProgram in Public Health, College of Health Sciences, University of California, Irvine, CA, USA.
Guangzhou Development Zone Hospital · CNSouthern Medical University · CNUniversity of California, Irvine · US

Funding

National Natural Science Foundation of China 31630011Science and Technology Planning Project of Guangzhou 201804020084
6 · The paper itself

Abstract

backgroundAedes (Stegomyia) albopictus (Skuse, 1894) is the main vector of dengue virus in China. The resistance to insecticides is a huge obstacle for the control of this species, and determining its resistance status and mechanisms in China is essential for the implementation of vector management strategies.

methodsWe have investigated the larval and adult resistance status of Ae. albopictus to deltamethrin in eight field populations in China. Mutations at the voltage-gated sodium channel gene, related to the knockdown resistance (kdr) effect, were detected by sequencing of PCR products. The eight field populations were examined for pyrethroid resistance using the World Health Organization standard bioassays, and the association between the mutations and phenotypic resistance was tested.

resultsThe eight field populations of larvae of Ae. albopictus in China exhibited high resistance to deltamethrin; the RR

conclusionThere were different degrees of resistance to deltamethrin in field Ae. albopictus populations in China. The longest knockdown time and lowest mortality rate observed in Ae. albopictus population in Guangzhou indicate the severity of high resistance to deltamethrin. The patchy distribution of deltamethrin resistance and kdr mutations in Ae. albopictus mosquitoes suggests the necessity for resistance management and developing counter measures to mitigate the spread of resistance.

Indexed as

AedesAnimalsChinaInsecticide ResistanceInsect ProteinsLarvaMutationNitrilesPyrethrinsdecamethrinInsect ProteinsNitrilesPyrethrinsAedes albopictusDeltamethrinkdrResistance

Identifiers

PMID34922622
PMCPMC8684111
OpenAlexW4200611404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.