ArticleKidney research and clinical practice2021
The roles of sodium and volume overload on hypertension in chronic kidney disease.
Article in Kidney research and clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Autonomic imbalance and vascular injury in hypertensive chronic kidney disease: mechanisms and clinical potential of ultrasound-guided sympathetic blockade.Frontiers in neuroscience · 2026Review
- Article
- Target blood pressure in Korean hemodialysis patients for optimal survival.Kidney research and clinical practice · 2025Article
- Global, regional, and National Burden of chronic kidney disease attributable to dietary risks from 1990 to 2021.Frontiers in nutrition · 2025Article
- Evaluation of aldosterone to direct renin ratio, low renin and related Phenotypes in Afro-Colombian patients with apparent treatment resistant hypertension.Scientific reports · 2024Article
- The case for a ketogenic diet in the management of kidney disease.BMJ open diabetes research & care · 2024Review
- The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990-2019 in China.Frontiers in nutrition · 2024Article
- Association of serum creatinine to cystatin C to waist circumference ratios and hypertension: evidence from China health and retirement longitudinal study.Frontiers in endocrinology · 2024Article
- Diastolic function in chronic kidney disease.Clinical kidney journal · 2023Review
- Diagnosis and treatment of hypertension in dialysis patients: a systematic review.Clinical hypertension · 2023Review
- Obesity-related hypertension and chronic kidney disease: from evaluation to management.Kidney research and clinical practice · 2023Article
- Therapeutic roles of thiazides and loop diuretics in blood pressure control and renal protection against chronic kidney disease.Clinical hypertension · 2023Review
- Recent updates in therapeutic approach using tolvaptan for autosomal dominant polycystic kidney disease.The Korean journal of internal medicine · 2023Review
- Global, regional, and national burden of chronic kidney disease attributable to high sodium intake from 1990 to 2019.Frontiers in nutrition · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular (CV) events, and the disease burden is rising rapidly. An important contributor to CV events and CKD progression is high blood pressure (BP). The main mechanisms of hypertension in early and advanced CKD are renin-angiotensin system activation and volume overload, respectively. Sodium retention is well known as a factor for high BP in CKD. However, a BP increase in response to total body sodium or volume overload can be limited by neurohormonal modulation. Recent clinical trial data favoring intensive BP lowering in CKD imply that the balance between volume and neurohormonal control could be revisited with respect to the safety and efficacy of strict volume control when using antihypertensive medications. In hemodialysis patients, the role of more liberal use of antihypertensive medications with the concept of functional dry weight for intensive BP control must be studied.
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