Evidence map›Paper›PMID 34922272›Full record

ArticleBiomaterials2022

3D-printed oxygen-releasing scaffolds improve bone regeneration in mice.

Ashley L Farris, Dennis Lambrechts, Yuxiao Zhou, Nicholas Y Zhang, Naboneeta Sarkar, Megan C Moorer, Alexandra N Rindone, Ethan L Nyberg, Alexander Perdomo-Pantoja, S J Burris and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. 3D printed OActa biomaterialia · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ashley L FarrisDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dennis LambrechtsDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuxiao ZhouDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicholas Y ZhangDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Naboneeta SarkarDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Megan C MoorerDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Alexandra N RindoneDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ethan L NybergDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexander Perdomo-PantojaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
S J BurrisDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kendall FreeTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Timothy F WithamDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ryan C RiddleDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Warren L GraysonDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: wgrayson@jhmi.edu.
Johns Hopkins University · USUnited States Department of Veterans Affairs · US

Funding

BIOMEDICAL ENGINEERING TRAINING PROGRAMT32GM007057 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O, KARCHIN, RACHEL · 1985 to 2023
$10.4M
Oxygen-eluting scaffolds for cranial bone regenerationR01DE027957 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI GRAYSON, WARREN L, PATHAK, ARVIND P · 2019 to 2023
$2.4M
Investigating the Role of Hypoxic Signaling on Adipose-Derived Stem Cell OsteogenesisF31AR075368 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI FARRIS, ASHLEY · 2020 to 2021
$74k
NIAMS NIH HHS F31 AR075368NIDCR NIH HHS R01 DE027957NIGMS NIH HHS T32 GM007057
6 · The paper itself

Abstract

Low oxygen (O

Indexed as

OsteogenesisTissue EngineeringAnimalsBone RegenerationCell DifferentiationMiceOxygenPolyestersPrinting, Three-DimensionalTissue ScaffoldsOxygenPolyesters3D-printingAdipose-derived stem cellsBone tissue engineeringMicrotanksOsteogenesisOxygen delivery

Identifiers

PMID34922272
PMCPMC8918039
OpenAlexW4200610923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.