Evidence map›Paper›PMID 34922194›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2022

Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone.

Keiko Wada, Masaki Sonoda, Ethan Firestone, Kazuki Sakakura, Naoto Kuroda, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Takahiro Mihara, Takahisa Goto and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Normative atlases of high-frequency oscillation and spike rates under Sevoflurane anesthesia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  6. Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Keiko WadaDepartment of Anesthesiology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 1878551, Japan; Department of Anesthesiology and Critical Care, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan.
Masaki SonodaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan.
Ethan FirestoneDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Physiology, Wayne State University, Detroit, MI 48201, USA.
Kazuki SakakuraDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, University of Tsukuba, Tsukuba 3058575, Japan.
Naoto KurodaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Yutaro TakayamaDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan; Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 1878551, Japan.
Keiya IijimaDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 1878551, Japan.
Masaki IwasakiDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 1878551, Japan.
Takahiro MiharaDepartment of Anesthesiology and Critical Care, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan; Department of Health Data Science, Yokohama City University Graduate School of Data Science , Yokohama 2360027, Japan.
Takahisa GotoDepartment of Anesthesiology and Critical Care, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan.
Eishi AsanoDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA. Electronic address: easano@med.wayne.edu.
Tomoyuki MiyazakiDepartment of Anesthesiology and Critical Care, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan; Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 2360004, Japan. Electronic address: johney@yokohama-cu.ac.jp.
National Center of Neurology and Psychiatry · JPChildren's Hospital of Michigan · USYokohama City University · JPDetroit Medical Center · USWayne State University · US

Funding

Functional brain mapping in pediatric neurosurgeryR01NS064033 · NINDS · WAYNE STATE UNIVERSITY · PI EISHI ASANO · 2009 to 2026
$5.7M
NINDS NIH HHS R01 NS064033
6 · The paper itself

Abstract

objectivePhase-amplitude coupling between high-frequency (≥150 Hz) and delta (3-4 Hz) oscillations - modulation index (MI) - is a promising, objective biomarker of epileptogenicity. We determined whether sevoflurane anesthesia preferentially enhances this metric within the epileptogenic zone.

methodsThis is an observational study of intraoperative electrocorticography data from 621 electrodes chronically implanted into eight patients with drug-resistant, focal epilepsy. All patients were anesthetized with sevoflurane during resective surgery, which subsequently resulted in seizure control. We classified 'removed' and 'retained' brain sites as epileptogenic and non-epileptogenic, respectively. Mixed model analysis determined which anesthetic stage optimized MI-based classification of epileptogenic sites.

resultsMI increased as a function of anesthetic stage, ranging from baseline (i.e., oxygen alone) to 2.0 minimum alveolar concentration (MAC) of sevoflurane, preferentially at sites showing higher initial MI values. This phenomenon was accentuated just prior to sevoflurane reaching 2.0 MAC, at which time, the odds of a site being classified as epileptogenic were enhanced by 86.6 times for every increase of 1.0 MI.

conclusionsIntraoperative MI best localized the epileptogenic zone immediately before sevoflurane reaching 2.0 MAC in this small cohort of patients. SIGNIFICANCE: Prospective, large cohort studies are warranted to determine whether sevoflurane anesthesia can reduce the need for extraoperative, invasive evaluation.

Indexed as

AdolescentAnesthesia, GeneralAnesthetics, InhalationBrainBrain WavesChildChild, PreschoolDrug Resistant EpilepsyElectrocorticographyEpilepsies, PartialHumansNeurosurgical ProceduresProspective StudiesSevofluraneYoung AdultAnesthetics, InhalationSevofluraneelectrocorticography (ECoG)General anesthesiahigh-frequency oscillation (HFO)intracranial electroencephalography (EEG)Ripples

Identifiers

PMID34922194
PMCPMC8766927
OpenAlexW3214885778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.