ArticleJournal of neuroimmunology2022
Stellate ganglion block reduces symptoms of Long COVID: A case series.
Article in Journal of neuroimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study
Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC)
Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites
Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- A novel application of stellate ganglion block to improve sleep: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response.BMC anesthesiology · 2025Trial
- Effect of ultrasound-guided stellate ganglion block on inflammatory cytokines and postoperative recovery after partial hepatectomy: a randomised clinical trial.BMC anesthesiology · 2024Trial
- Article
- Effectiveness of ultrasound-guided pulsed radiofrequency of the stellate ganglion for pain management in painful blind eye: a prospective case series.Journal of translational medicine · 2026Article
- Case Report: Relief of long-standing severe motion sickness following stellate ganglion block.Frontiers in neuroscience · 2026Article
- An overview of clinical presentation and management of long COVID.The Nurse practitioner · 2025Review
- Olfactory impairment associated with reduced physical capacity 24 months after COVID-19.Brain, behavior, & immunity - health · 2025Article
- Stellate Ganglion Block for the Management of Long COVID Symptoms: A Retrospective Cohort Study.Cureus · 2025Article
- The Ganglia of the Head and Neck: Clinical Relevance for the Interventional Pain Physician.Current pain and headache reports · 2025Review
- Common Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications.Seminars in interventional radiology · 2025Review
- Article
- Parosmia: Pathophysiology and Management.Current allergy and asthma reports · 2025Review
- Case Report: Celiac plexus block improves gastrointestinal Long COVID symptoms.Frontiers in neuroscience · 2025Article
- Post-COVID-19 manifestations among college students: shedding the light on young adults' health.BMC public health · 2024Article
- Long-Term Neurologic Complications of COVID-19: A Practical Overview The authors present an overview of the presentation and management of common neurologic symptoms associated with long COVID.Practical neurology (Fort Washington, Pa.) · 2024Article
- SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia.International journal of molecular sciences · 2024Article
- Clinical studies in COVID-related olfactory disorders: Review of an institutional experience.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Long-COVID autonomic syndrome in working age and work ability impairment.Scientific reports · 2024Observational
- Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia.BMJ open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After recovering from COVID-19, a significant proportion of symptomatic and asymptomatic individuals develop Long COVID. Fatigue, orthostatic intolerance, brain fog, anosmia, and ageusia/dysgeusia in Long COVID resemble "sickness behavior," the autonomic nervous system response to pro-inflammatory cytokines (Dantzer et al., 2008). Aberrant network adaptation to sympathetic/parasympathetic imbalance is expected to produce long-standing dysautonomia. Cervical sympathetic chain activity can be blocked with local anesthetic, allowing the regional autonomic nervous system to "reboot." In this case series, we successfully treated two Long COVID patients using stellate ganglion block, implicating dysautonomia in the pathophysiology of Long COVID and suggesting a novel treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.