ArticleJournal of psychiatric research2022
Subthreshold depressive symptoms relate to cuneus structure: Thickness asymmetry and sex differences.
Article in Journal of psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 15 citations in OpenAlex.
- Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies.International journal of geriatric psychiatry · 2025Trial
- Resting-state functional MRI analysis of the brain's adaptation to chronic hypoxia: disease and environment.Quantitative imaging in medicine and surgery · 2026Article
- Increased functional integration of emotional control network across the adult lifespan.Aging brain · 2026Article
- Article
- Altered resting-state functional connectivity in individuals at risk for Alzheimer's disease: a longitudinal study.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Despite the prominence of frontolimbic regions in depression research, recent studies also implicate posterior brain regions, including the cuneus. The current study examined the relationship between depressive symptoms and asymmetry in cuneal cortical thickness in healthy adults between the ages of 18 and 81 with primarily subthreshold levels of depressive symptoms. An asymmetry index was calculated for cortical thickness in the cuneus [(left - right) × 100/(left + right)], and regression analyses were conducted with total scores on the Center for Epidemiologic Studies Depression Scale predicting this asymmetry index, controlling for age and sex. Higher depressive symptoms were associated with a left > right asymmetry in cuneal cortical thickness, reflecting greater cortical thickness in the left hemisphere compared to right hemisphere. Follow-up analyses examining CES-D subscales showed significant effects for somatic symptoms of depression, but not negative affect or anhedonia. Analyses stratified by sex yielded significant effects in men but not in women. Results of this preliminary study further support the cuneus' role in depression and highlight the importance of examining symptom dimensions and sex differences in the neurobiology of depression.
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